Reversible photoswitching aggregation and dissolution of spiropyran-functionalized copolymer and light-responsive FRET process  

作　　者：Lei-Xiao Yu Yang Liu Si-Chong Chen Yue Guan Yu-Zhong Wang 

机构地区：[1]Center for Degradable and Flame-Retardant Polymeric Materials,State Key Laboratory of Polymer Materials Engineering,College of Chemistry,National Engineering Laboratory of Eco-Friendly Polymeric Materials (Sichuan),Sichuan University

出　　处：《Chinese Chemical Letters》2014年第3期389-396,共8页中国化学快报（英文版）

基　　金：supported by the National Natural Science Foundation of China (Nos. 51073106 and 51121001);Program for Changjiang Scholars and Innovative Research Team in University of Ministry of Education of China (No. IRT1026)

摘　　要：Well-defined, reversibly light-responsive amphiphilic diblock copolymer grafted with spiropyran, was prepared by reversible addition-fragmentation chain transfer （RAFT） polymerization. The copolymer self-assembles into polymeric micelles in water and exhibits reversible dissolution and re-aggregation characteristics upon ultraviolet （UV） and visible （Vis）-light irradiation. The fluorescence response of spiropyran immobilized onto the copolymer was light switchable. When nitrobenzoxadiazolyl derivative （NBD） dyes are encapsulated into the core of the micelles, a reversible, light-responsive, dual-color fluorescence resonance energy transfer （FRET） system is constructed and processed, which is well regulated by alternatively UV/vis irradiation. We anticipate these photoswitchable and FRET lighting up nanoparticles will be useful in drug delivery and cell imaging or tracking synchronously.Well-defined, reversibly light-responsive amphiphilic diblock copolymer grafted with spiropyran, was prepared by reversible addition-fragmentation chain transfer （RAFT） polymerization. The copolymer self-assembles into polymeric micelles in water and exhibits reversible dissolution and re-aggregation characteristics upon ultraviolet （UV） and visible （Vis）-light irradiation. The fluorescence response of spiropyran immobilized onto the copolymer was light switchable. When nitrobenzoxadiazolyl derivative （NBD） dyes are encapsulated into the core of the micelles, a reversible, light-responsive, dual-color fluorescence resonance energy transfer （FRET） system is constructed and processed, which is well regulated by alternatively UV/vis irradiation. We anticipate these photoswitchable and FRET lighting up nanoparticles will be useful in drug delivery and cell imaging or tracking synchronously.

关 键 词：RAFT polymerizationSpiropyranLight-responsiveSelf-assembleFluorescence resonance energy transfer（FRET） 

分 类 号：O633.5[理学—高分子化学]