An eco-friendly water mediated synthesis of 1,2,3-triazolyl-2-aminopyrimidine hybrids as highly potent anti-bacterial agents  

作　　者：Sangaraiah Nagarajan Poovan Shanmugavelan Murugan Sathishkumar Ramasamy Selvi Alagusundaram Ponnuswamy Hariharan Harikrishnan Vellasamy Shanmugaiah 

机构地区：[1]Department of Organic Chemistry,School of Chemistry,Madurai Kamaraj University [2]Department of Microbial Technology,School of Biological Sciences,Madurai Kamaraj University

出　　处：《Chinese Chemical Letters》2014年第3期419-422,共4页中国化学快报（英文版）

基　　金：the UGC (BSR) and DST-PURSE for financial support;Department of Science and Technology, New Delhi, India for funds under the IRHPA program for the purchase of a NMR spectrometer

摘　　要：An elegant and efficient synthesis of novel 1,2,3-triazole fused 2-aminopyrimidine hybrids has been accomplished for the first time in the green solvent viz, water. The hybrid molecules exhibit significant anti-bacterial activity when screened against three human pathogens viz. Staphylococcus aureus, Pseudomonas aeruginosa and Klebsiella pneumoniae. In comparison to the commercially marketed drug tetracycline, some of them are equally potent and a few are more potent.An elegant and efficient synthesis of novel 1,2,3-triazole fused 2-aminopyrimidine hybrids has been accomplished for the first time in the green solvent viz, water. The hybrid molecules exhibit significant anti-bacterial activity when screened against three human pathogens viz. Staphylococcus aureus, Pseudomonas aeruginosa and Klebsiella pneumoniae. In comparison to the commercially marketed drug tetracycline, some of them are equally potent and a few are more potent.

关 键 词：Water promotedAntibacterial1 2 3-TriazolePyrimidine 

分 类 号：TQ463.5[化学工程—制药化工]