Synthesis and antibacterial activity of ethyl 2-amino-6-methyl-5-oxo-4-aryl-5,6-dihydro-4H-pyrano[3,2-c]quinoline-3-carboxylate  

作　　者：Sakineh Asghari Samaneh Ramezani Mojtaba Mohseni 

机构地区：[1]Department of Organic Chemistry,Faculty of Chemistry,University of Mazandaran [2]Nano and Biotechnology Research Group,University of Mazandaran [3]Department of Microbiology,Faculty of Sciences,University of Mazandaran

出　　处：《Chinese Chemical Letters》2014年第3期431-434,共4页中国化学快报（英文版）

基　　金：supported by the Research Council of the University of Mazandaran in Iran

摘　　要：The three-component reaction of 4-hydroxy-l-methyl-2（1H）-quinolinone, aromatic aldehydes and ethyl cyanoacetate was carried out in the presence of a catalytic amount of 4-dimethyl aminopyridine （DMAP） in aqueous ethanol. The reactions result in the formation of pyranoquinoline derivatives in excellent yields. Antibacterial activity has been evaluated against Gram positive and Gram negative bacteria for some of the synthesized compounds. The results indicated that these compounds are moderately effective against bacterial growth and their effectiveness is highest against Pseudomonas aeruginosa.The three-component reaction of 4-hydroxy-l-methyl-2（1H）-quinolinone, aromatic aldehydes and ethyl cyanoacetate was carried out in the presence of a catalytic amount of 4-dimethyl aminopyridine （DMAP） in aqueous ethanol. The reactions result in the formation of pyranoquinoline derivatives in excellent yields. Antibacterial activity has been evaluated against Gram positive and Gram negative bacteria for some of the synthesized compounds. The results indicated that these compounds are moderately effective against bacterial growth and their effectiveness is highest against Pseudomonas aeruginosa.

关 键 词：Three-component reactionPyranoquinoline4-Dimethyl aminopyridine （DMAP）Antibacterial activity 

分 类 号：O621.2[理学—有机化学] TQ460.1[理学—化学]