头孢地尼对细菌感染小鼠的体内抗菌作用  

In Vivo Antibacterial Action of Cefdinir in Mice with Bacterial Infection

作　　者：刘琳[1] 卢亚兰[1] 杜娟[2] 

机构地区：[1]郑州大学附属郑州中心医院药学部,郑州450007 [2]河南省肿瘤医院药剂科,郑州450008

出　　处：《中国医院用药评价与分析》2014年第2期145-147,共3页Evaluation and Analysis of Drug-use in Hospitals of China

摘　　要：目的:探讨头孢地尼对郑州市分离的致病菌感染小鼠的体内抗菌作用。方法:以最小致死量(MLD)0.5 ml腹腔注射金黄色葡萄球菌、肺炎链球菌、肺炎克雷伯菌和大肠埃希菌感染小鼠,建立小鼠全身感染模型,灌胃以不同剂量的头孢地尼0.5 ml,以头孢妥仑匹酯为阳性对照,并以半数有效量(ED50)为观察指标,研究头孢地尼的体内抗菌活性。结果:头孢地尼对金黄色葡萄球菌、肺炎链球菌、肺炎克雷伯菌和大肠埃希杆菌的ED50分别为0.12、0.08、1.25、2.18 mg/kg,头孢妥仑匹酯对上述菌株的ED50值分别为16.7、19.5、7.12、1.65 mg/kg。结论:头孢地尼体内抗球菌的活性远高于头孢妥仑匹酯,但其对大肠埃希杆菌的活性低于头孢妥仑匹酯,提示头孢地尼具有较优的抗球菌作用。OBJECTIVE：To evaluate the in vivo antibacterial activity of cefdinir in the mice infected with pathogenic bacteria isolated in Zhengzhou.METHODS：The mice were intraperitoneally injected with 0.5 ml minimum lethal dose bacteria staphylococcus aureus,streptococcus pneumoniae,klebsiella pneumoniae and Escherichia coli to establish experimental model of systemic infection,followed by intragastric administration with different dosage of cefdinir （0.5 ml） with Cefditoren pivoxil as the positive control and the median effective dose （ED50） as outcome measure to study the in vivo antibacterial activity of cefdinir.RESULTS：The values of EDs0 of the cefdinir against staphylococcus aureus,streptococcus pneumoniae,klebsiella pneumoniae and Escherichia coli were 0.12 mg/kg,0.08 mg/kg,1.25 mg/kg and 2.18 mg/kg,respectively; the values of ED50 of the Cefditoren pivoxil against staphylococcus aureus,streptococcus pneumoniae,klebsiella pneumoniae and Escherichia coli were 16.7 mg/kg,19.5 mg/kg,7.12 mg/kg and 1.65 mg/kg,respectively.CONCLUSION：Cefdinir showed higher in vivo antibacterial activity against coccus yet lower antibacterial activity against Escherichia coli than did cefditoren pivoxil,which is suggestive of the better antibacterial activity of cefdinir than cefditoren pivoxil against coccus.

关 键 词：头孢地尼 头孢妥仑匹酯 体内抗菌活性 半数有效量 

分 类 号：R965[医药卫生—药理学]