蒙药辅助治疗老年慢性心衰患者的临床疗效  

Clinical Effects of Adjuvant Therapy on Elderly Chronic Heart Failure Patients with Traditional Mongolian Medicine

作　　者：刘萨仁[1] 佟玉清[1] 金桃[1] 张青山[1] 包布仁白乙拉[1] 

机构地区：[1]内蒙古民族大学附属医院蒙医心内科,内蒙古通辽028000

出　　处：《中国实验方剂学杂志》2014年第7期208-211,共4页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：内蒙古自然科学基金项目(2011MS1165)

摘　　要：目的:探讨蒙药治疗老年慢性心力衰竭(CHF)患者的临床疗效及对患者血液流变学、血浆D-二聚体的影响。方法:将108例老年CHF患者随机按入院前后分成对照组和观察组各54例。对照组采用西药强心、利尿、扩血管等常规治疗;观察组在对照组治疗的基础上加用蒙药治疗,达力-16味散每次5 g早饭后口服,蒺藜-3味汤每次5 g午饭后口服,绍沙-7味丸每次3 g晚睡前口服。两组疗程均为12周。进行治疗前后纽约心脏病协会(NYHA)心功能分级和Lee氏心衰计分;采用超声心动图测定治疗前后心室射血分数(LVEF)、左室舒张末期内径(LVDD)和心输出量(CO);进行治疗前后血液流变学、血浆D-二聚体和血浆N端脑钠肽前体(NT-proBNP)检测。结果:治疗后观察组总有效率为87.04%优于对照组的70.37%(P<0.05);治疗后观察组Lee氏心衰积分低于对照组(P<0.01);治疗后观察组LVDD低于对照组(P<0.05);观察组LVEF和CO高于对照组(P<0.01);治疗后观察组NT-proBNP,D-二聚体水平低于对照组(P<0.01);治疗后观察组全血黏度、红细胞变形指数、纤维蛋白原的改善优于对照组(P<0.05)。结论:在西医常规治疗的基础上给予老年CHF患者达力-16味散、蒺藜-3味汤和绍沙-7味丸3种蒙药治疗,能改善老年CHF患者心功能,减轻临床症状,提高临床疗效;还能改善患者血液流变学及血液高凝状态,值得临床使用。Objective： The purpose is to discuss the clinical effects of traditional Mongolian medicine to treat chronic cardiac failure（CHF） and influence of hemorheology,plasma D-dimer on patients. Method： One hundred and eight cases of patients with were randomly divided into control group （54 cases） and observation group （54 cases）.In control group,patients were treated with western medicine conventional therapy by cardiac,diuresis,vascular dilation and so on. In observation group,besides based on control group,patients added traditional Mongolian medicine,Dali-16 wei san 5 g,taken orally after breakfast;Jili-3 wei decoction 5 g,taken orally after lunch;Shaosha-7wei pill 3 g,taken orally before sleep.Both groups were treated for 12 weeks.Record New york heart association（NYHA） cardiac functional grading and Lee＇s heart failure scores before and after treatment.Measure the left ventricular ejection fraction （LVEF）,left ventricular end diastolic diameter（LVDD） and cardiac output（CO） by ultrasonic cardiogram at pretherapy and post-treatment.Detect hemorheology,plasma D-dimer and N-terminal plasma brain natriuretic peptide precursor （NT-proBNP）before and after treatment. Result： After treatment,the total effective rate of the observation group was 87.4% superior to 70.37% of the control group（P〈0.05）. the Lee＇s heart failure scores of the observation group were lower than the control group（P〈0.01）, Left ventricular end diastolic dimension（LDVV） of the observation group was lower than the control group（P〈0.05）,LVEF and CO of the observation group were higher than the the control group（P〈0.01）. The level of NT-proBNP and D-dimer of the observation group were lower than the control group（P〈0.01）. The improvement of blood viscosity, erythrocyte deformation index（RCD） and fibrinogen of the observation group were superior to the control group（P〈0.05）. Conclusion： Based on the routine western medicine therapy,for the elderly patients,it can impr

关 键 词：慢性心力衰竭 蒙医蒙药 达力-16味散 蒺藜-3味汤 绍沙-味丸 血液流变学 D-二聚体 

分 类 号：R287[医药卫生—中药学]