高良姜化学成分及药理活性的研究  

Advances in Studies on Chemical Constituents in Alpiniae Officinarum Rhizoma and their Pharmacological Activities

作　　者：李洪福[1,2] 李永辉[1,2] 王勇[1,2] 魏娜[1] 谭银丰[1,2] 张俊清[1,2] 

机构地区：[1]海南医学院药学院,海口571101 [2]海南医学院海南省热带药用植物研究与开发重点实验室,海口571101

出　　处：《中国实验方剂学杂志》2014年第7期236-244,共9页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：国家"十二五"区域基地项目(SQ2010BAJY1411-07-02);海口市重点科技计划项目(ZDXM20110037)

摘　　要：对近年来有关高良姜化学成分和药理作用的研究进行介绍,高良姜为一种常用中药,其化学成分主要包括挥发油类、黄酮类、二芳基庚烷类、苯丙素类、糖苷类等。药理学研究表明高良姜具有抗菌作用、抗病毒作用、抗肿瘤作用、抗氧化作用、抗胃肠道出血作用、抗溃疡作用和胃黏膜保护作用等。无论是高良姜粗提物还是其中所包含的具体的化学成分都表现出较好的药理活性,尤其是高良姜中的二芳基庚烷类化合物和黄酮类化合物的药理活性的研究比较广泛,他们在抗肿瘤、抗氧化以及与其他药物联合应用抗多重耐药菌株方面的应用日益受到人们的关注。今后在探讨高良姜中的二芳基庚烷类化合物和黄酮类化合物的药理活性时,更应该注重同类成分之间的相互比较,寻找药理活性必须基团,明确构效关系,深入探讨作用机制,进一步促进高良姜药材的综合开发利用。Alpiniae officinarum rhizoma has been used as flavonoids, diarylheptanoids, phenylpropanoids, glycosides and a folk medicine and other constituents. pharmacological research reports, this medicine has various pharmacological activities contains essential oil, According to recent including antimicrobial activity, antiviral activity, antitumous activity, antioxidant activity, gastric ulcer therapy and as a hemostat in the treatment of gastrointestinal hemorrhages. For further exploitation and sustainable utilization of this folk medicine, the information about the chemical constituents and pharmacological activities of the rhizoma of Alpinia officinarum that have appeared in recent years were summarized.

关 键 词：高良姜 二芳基庚烷类 黄酮类 糖苷类 药理作用 

分 类 号：R284.1[医药卫生—中药学]