非水电位滴定法测定氢溴酸西酞普兰原料药含量的改进  

Optimization of Determination Method of Citalopram Hydrobromide by Non-aqueous Potentiometric Titration

作　　者：胡猛慎[1] 洪志玲[1] 黄剑英[1] 李玲玲[1] 

机构地区：[1]厦门市药品检验所,厦门361012

出　　处：《中国现代应用药学》2014年第3期323-325,共3页Chinese Journal of Modern Applied Pharmacy

基　　金：厦门市科技平台(3502Z20121035)

摘　　要：目的建立革除汞盐的非水电位滴定法测定氢溴酸西酞普兰原料药的含量。方法采用以冰醋酸-醋酐(1∶5)为溶剂的高氯酸电位滴定法测定氢溴酸西酞普兰原料药的含量。结果成功革除醋酸汞,所得实验结果与原方法的测定结果基本一致。结论建立的方法革除了汞盐试剂,滴定突越明显,方法简便、准确,适于氢溴酸西酞普兰原料药的含量测定。OBJECTIVE To establish a determination method of citalopram hydrobromide by non-aqueous potentiometric titration without using mercurate. METHODS Non-aqueous potentiometric titration was used for assay. Citalopram hydrobromide was dissolved in glacial acetic acid-acetic anhydride（1 ： 5） instead of mercuric salt. RESULTS The results of the improved method were same with that of the original methods. CONCLUSION The improved method discards mercuric salt and obtain an abrupt change of the titration cruve. It is simple and accurate for the determination of citalopram hydrobromide.

关 键 词：非水电位滴定 革除汞盐 氢溴酸西酞普兰 

分 类 号：R917.105[医药卫生—药物分析学]