内皮素受体及其受体拮抗剂在心血管疾病中的作用  

Effect of Endothelin Receptors, Endotheline Receptor Antagonist on Cardiovascular Disease

作　　者：李培武[1,2] 伏旭[2] 傅仲学[1] 

机构地区：[1]重庆医科大学附属第一医院普外科,重庆400016 [2]兰州大学第二医院急救中心,兰州730030

出　　处：《中国现代应用药学》2014年第3期376-380,共5页Chinese Journal of Modern Applied Pharmacy

基　　金：甘肃省技术研究与开发专项计划项目(0709TCYA062)

摘　　要：目的探讨内皮素受体在心血管疾病(cardiovascular disease,CVD)生理病理中的作用,为内皮素受体拮抗剂的新药合成和发现提供参考。方法综述了近年来国内外相关报道,并对临床研究和作用机制进行讨论,重点强调了内皮素受体,尤其是ETB受体在不同组织具有不同的病理生理学应答机制,发挥不同生理学作用。结果内皮素受体在CVD治疗中发挥重要作用。结论内皮素受体拮抗剂是临床治疗CVD的潜在有效手段。OBJECTIVE To discuss the role of endothelin receptors in physiological and pathological cardiovascular diseases（CVD）, and provide a reference in new drug synthesis and discovery. METHODS According to the correlative reports in recent years, endothelin receptors, especially ETB receptors, and its mechanism and response in the pathophysiology in different organizations were discussed in clinical research. RESULTS Endothelin receptor played an important role in CVD therapy. CONCLUSION Endothelin receptor antagonists have been assumed as potential strategies for the treatment in CVD.

关 键 词：内皮素受体 内皮素-1 心血管疾病 

分 类 号：R972[医药卫生—药品]