48例女性油漆工发生新生儿唇腭裂致病因素分析  

Analysis on etiological factors of neonates with cleft lip and palate in 48 female painting trades workers

作　　者：张建丽[1] 李福军[1] 李宏[1] 

机构地区：[1]河南科技大学第一附属医院口腔颌面外科,河南洛阳471003

出　　处：《中国妇幼保健》2014年第10期1524-1525,共2页Maternal and Child Health Care of China

摘　　要：目的：探讨发生新生儿唇腭裂的女性油漆工致病因素，为预防唇腭裂提供临床依据。方法：回顾性分析该院2009年3月～2012年10月收治唇腭裂患儿及产前检查过程中筛查出唇腭裂并行引产胎儿48例临床病史资料，总结并分析可能致病因素。结果：48例患儿母亲均为油漆工，且怀孕3个月前均正常工作，其中怀孕时间为工作后0．5年、工作后0．5～1．5年、工作后1．5～3年及工作后3年以上例数分别为4例、10例、11例、23例，所占百分比分别为8．4％、20．8％、22．9％、47．9％；工作后3年以上怀孕女性油漆工怀有唇腭裂胎儿所占百分比明显高于工作后3年以内怀孕者，组问比较差异有统计学意义（P〈0．05）。结论：唇腭裂胎儿出现与母亲接触油漆有关，且其发生与工作时间密切相关，有关部门应做好优生优育及职业病防护相关知识宣传，提醒孕妇要增强职业防护意识，积极参加孕前及孕期检查，从而有效降低唇腭裂发生风险，提高生育质量。Objective： To explore the etiological factors of neonates with cleft lip and palate in female painting trades workers, provide a clinical basis for preventing cleft lip and palate. Methods： The clinical data of 48 female painting trades workers with cleft lip and palate fetuses （induced abortion） in the hospital from March 2009 to October 2012 were analyzed retrospectively, the probable etiological factors were summarized and analyzed. Results： All the 48 female painting trades workers worker normally at three months before pregnancy, and the numbers of them getting pregnancy at 0. 5, 0. 5 - 1.5, 1.5 - 3, and more than 3 years after starting working were 4, 10, 11, and 23, the proportions were 8.4%, 20. 8%, 22. 9%, and 47.9%, respectively; the proportion of fetuses with cleft lip and palate in fe- male paitlting trades workers starting working for more than 3 years was statistically significantly higher than that in female painting trades workers starting working for less than 3 years （P 〈 0.05 ） . Conclusion ：＂The occurrence of fetal cleft !ip and palate is related to maternal exposure to oil paint, and it is closely correlated with working time ; the related departments should enhance publicity of related knowledge about eugenics and prevention and protection of occupational disease, the pregnant women should be advised to strengthen awareness of professional prevention and protection and actively participate in progestational and prenatal examination to reduce the risk of cleft lip and palate and improve birth quality effectively.

关 键 词：新生儿 唇腭裂 女性 油漆工 致病因素 

分 类 号：R715[医药卫生—妇产科学]