黄芪多糖抗疲劳作用研究  

Studies on Anti-fatigue Effect of Polysaccharide from Radix astragali

作　　者：吴铭[1] 周桃英[2] 陈年友[2,3] 陈国安[2] 

机构地区：[1]吉林工商学院/粮油食品深加工吉林省高校重点实验室,长春130062 [2]黄冈职业技术学院生物化工学院,湖北黄冈438002 [3]黄冈师范学院化学工程学院,湖北黄冈438000

出　　处：《湖北农业科学》2014年第1期175-177,共3页Hubei Agricultural Sciences

基　　金：吉林省高校重点实验室科研资金资助项目;湖北省自然科学面上资金项目(2007BAB064);黄冈职业技术学院科研资金资助项目

摘　　要：采用灌胃法,对96只小鼠进行黄芪(Radix astragali)多糖低剂量治疗组50 mg/kg(LPG)、中剂量治疗组100 mg/kg(MPG)、高剂量治疗组200 mg/kg(HPG)处理,以灌胃去离子水为对照组(CG),连续灌胃28 d,对小鼠负重力竭游泳时间、血乳酸、肝糖原的含量及肝组织中SOD、GSH-Px的活性等指标进行测定,以研究黄芪多糖的抗疲劳作用。结果表明,黄芪多糖可延长小鼠负重力竭游泳时间,降低机体血乳酸的积累,增加肝糖原的储备,起到延缓疲劳发生、提高运动能力的作用;黄芪多糖能提高小鼠肝组织中SOD、GSH-Px抗氧化酶的活性,具有抗氧化损伤作用,能保护运动诱导的氧化应激。Anti-fatigue effect of polysaccharide from Radix astragali was investigated. 96 male mice were divided into the following 4 experimental groups： low-dose treated group 50 mg/kg polysaccharide（LPG）, medium-dose treated group 100 mg/ kg polysaccharide （MPG）,high-dose treated group 200 mg/kg polysaccharide （HPG）,and dH20 control group （CG） for 28 consecutive days. The loading-weight exhausting swimming time, blood lactic acid, liver glycogen, SOD and GSH-Px concent in mice were determined. Results showed that polysaccharide from Radix astragali would significantly inhibit fatigue, which extended the loading-weight exhausting swimming time of mice, effectively delayed the increase of blood lactic acid, increased the storage of tissue glycogen, up-regulated SOD and GSH-Px activity during exercise and prevented oxidative stress.

关 键 词：黄芪(Radix astragali) 多糖 抗疲劳 小鼠 

分 类 号：R272.71[医药卫生—中医儿科学]