仿细胞外层膜结构壳聚糖纳米颗粒的制备及其控释性能研究  

Preparation and controlled release properties of cell outer membrane mimetic structures of chitosan nanoparticles

作　　者：宫铭[1] 徐强强[1] 褚佳[1] 汪晓芹[1] 宫永宽[2] 

机构地区：[1]西安科技大学化学与化工学院,西安710054 [2]西北大学化学与材料科学学院,合成与天然功能分子化学教育部重点实验室,西安710069

出　　处：《功能材料》2014年第4期39-42,共4页Journal of Functional Materials

基　　金：国家自然科学基金资助项目(20974087);西安科技大学博士启动资金资助项目(2013QDJ013)

摘　　要：采用模板聚合法以甲基丙烯酸(MA)、甲基丙烯酰氧乙基磷酰胆碱(MPC)为单体,以过硫酸钾为引发剂和壳聚糖进行聚合,制备具有仿细胞外层膜结构壳聚糖纳米颗粒。用动态光散射仪(DLS)、透射电镜(TEM)和zeta电位对纳米颗粒的粒径、zeta电位进行表征,并通过体外阿霉素控释实验对该纳米颗粒的控释性能进行研究。该仿细胞外层膜结构壳聚糖纳米颗粒将在基因治疗、药物控释等领域具有巨大的应用前景。该研究对于探索仿细胞外层膜结构纳米颗粒的控释性能具有重要的学术意义。The cell outer membrane mimetic structures of nanoparticles were prepared using methacrylic acid （MA）, 2-methacryloyloxyethyl phosphorylcholine （MPC） as monomer, potassium persulfate （KPS） and chi- tosan by template polymerization. The size distribution and structure properties of nanoparticles were character- ized by transmission electron microscopy （TEM）, dynamic light scattering （DLS） and zeta potential. The drug release properties of nanoparticles were estimated by doxorubicin in vitro release experiment. The cell outer membrane mimetic structures of nanoparticles might have potential applications in the fields of gene therapy and drug delivery. The controlled release properties had been an important academic significance on the study of outer cell membrane structures of nanoparticles.

关 键 词：壳聚糖 仿细胞外层膜结构 纳米颗粒 控释性能 

分 类 号：O636[理学—高分子化学]