Chemical investigation of the roots of Polygala sibirica L.  

作　　者：ZHOU Yu-Hong ZHANG Shui-Ying GUO Qiang CHAI Xing-Yun JIANG Yong TU Peng-Fei 

机构地区：[1]State Key Laboratory of Natural and Biomimetic Drugs,Peking University Health Science Center [2]Modern Research Center for Traditional Chinese Medicine,Beijing University of Chinese Medicine

出　　处：《Chinese Journal of Natural Medicines》2014年第3期225-228,共4页中国天然药物（英文版）

基　　金：financially supported by the National Key Technology R&D Program"New Drug Innovation"of China(Nos.2012ZX09301002-002-002,2012ZX09304-005);special funds for scientific research on traditional Chinese medicine(No.201307002);National Science Fund for Excellent Young Scholars(No.81222051)

摘　　要：AIM:To investigate the chemical constituents of the roots of Polygala sibirica L.(Polygalaceae) METHOD:The isolation was performed by solvent extraction and various chromatographic techniques,including silica gel,Sephadex LH-20,ODS,semi-preparative HPLC,and preparative TLC.The chemical structures were elucidated based on extensive spectroscopic analysis,including HR-ESI-MS and 1D- and 2D-NMR spectroscopic data.RESULTS:A total of sixteen compounds,including five xanthones(5,7–10),five saccharide esters(1,3,4,12,13),two flavonoids(14,16),two triterpenoids(11,15),one phenylpropanoid(6),and one benzophenone glycoside(2) were isolated.Their structures were determined as sibiricose A7(1),sibiriphenone A(2),polygalatenoside A(3),polygalatenoside C(4),lancerin(5),3,4,5-trimethoxycinnamic acid(6),6-hydroxy-1,2,3,7-tetramethoxyxanthone(7),1,3,7-trihydroxy-2-methoxyxanthone(8),onjixanthone II(9),1,2,3,6,7-pentamethoxyxanthone(10),presenegenin(11),3'-O-3,4,5-trimethoxycinnamoyl-6-O-4-methoxy benzoyl sucrose(12),tenuifoliside C(13),5,3'-dihydroxy-7,4'-dimethoxyflavonol-3-O-β-D-glucopyranoside(14),tenuifolin(15),and rhamnetin 3-O-β-D-glucopyranoside(16).CONCLUSION:Compounds 1 and 2 are two new compounds from P.sibirica.AIM： To investigate the chemical constituents of the roots of Polygala sibirica L. （Polygalaceae） METHOD： The isolation was performed by solvent extraction and various chromatographic techniques, including silica gel, Sephadex LH-20, ODS, semi-preparative HPLC, and preparative TLC. The chemical structures were elucidated based on extensive spectroscopic analysis, including HR-ESI-MS and 1 D- and 2D-NMR spectroscopic data. RESULTS： A total of sixteen compounds, including five xanthones （5, 7-10）, five saccharide esters （1, 3, 4, 12, 13）, two flavon- oids （14, 16）, two triterpenoids （11, 15）, one phenylpropanoid （6）, and one benzophenone glycoside （2） were isolated. Their struc- tures were determined as sibiricose A7 （1）, sibiriphenone A （2）, polygalatenoside A （3）, polygalatenoside C （4）, lancerin （5）, 3, 4, 5-trimethoxycinnamic acid （6）, 6-hydroxy-1, 2, 3, 7-tetramethoxyxanthone （7）, 1, 3, 7-trihydroxy-2-methoxyxanthone （8）, onjix- anthone II （9）, 1, 2, 3, 6, 7-pentamethoxyxanthone （10）, presenegenin （11）, 3＇-O-3, 4, 5-trimethoxycinnamoyl-6-O-4-methoxy ben- zoyl sucrose （12）, tenuifoliside C （13）, 5, 3＇-dihydroxy-7, 4＇-dimethoxyflavonol-3-O-β-D-glucopyranoside （14）, tenuifolin （15）, and rhamnetin 3-O-β-D-glucopyranoside （16）. CONCLUSION： Compounds 1 and 2 are two new compounds from P. sibirica.

关 键 词：Polygala sibirica POLYGALACEAE Sibiricose A7 Sibiriphenone A 

分 类 号：R284.1[医药卫生—中药学]