Chemical profiling of Jinqi Jiangtang tablets by HPLC-ESI-Q-TOF/MS  

作　　者：SUN Shi XIE Zhi-Shen LIU E-Hu YAN Yu-Ting XU Xiao-Jun LI Ping 

机构地区：[1]State Key Laboratory of Natural Medicines,China Pharmaceutical University

出　　处：《Chinese Journal of Natural Medicines》2014年第3期229-240,共12页中国天然药物（英文版）

基　　金：supported by the National Natural Science Foundation of China(No.81274159);"Eleventh-Five Years"Supporting Programs from the Ministry of Science and Technology of China(No.2008BAI51B01)

摘　　要：AIM： To profile the chemical constituents in Jinqi Jiangtang tablets. METHOD： Based on the chromatographic retention behavior, fragmentation patterns of chemical components, and published lit- eratures, a high-performance liquid chromatography coupled with electrospray ionization quadrnpole time-of-flight tandem mass spectrometry （HPLC-ESI-Q-TOF/MS） method was established to characterize and identify components in Jinqi Jiangtang tablets. RESULTS： A total of 52 chemical compounds, including eight iridoid glycosides, seven phenolic acids, twelve alkaloids, six fla- vonoids, and nineteen saponins, were identified in Jinqi Jiangtang tablets. CONCLUSION： The established method could serve as a powerful tool for structural characterization and quality control of this Chinese herbal preparation.AIM:To profile the chemical constituents in Jinqi Jiangtang tablets.METHOD:Based on the chromatographic retention behavior,fragmentation patterns of chemical components,and published literatures,a high-performance liquid chromatography coupled with electrospray ionization quadrupole time-of-flight tandem mass spectrometry(HPLC-ESI-Q-TOF/MS) method was established to characterize and identify components in Jinqi Jiangtang tablets.RESULTS:A total of 52 chemical compounds,including eight iridoid glycosides,seven phenolic acids,twelve alkaloids,six flavonoids,and nineteen saponins,were identified in Jinqi Jiangtang tablets.CONCLUSION:The established method could serve as a powerful tool for structural characterization and quality control of this Chinese herbal preparation.

关 键 词：HPLC-ESI-Q-TOF/MS Coptidis Rhizoma Astragali Radix Lonicerae Japonicae Flos Jinqi Jiangtang tablets MASSSPECTROMETRY 

分 类 号：R917[医药卫生—药物分析学]