医院配置中心注射用粉针剂药物残留问题的分析  

Analysis of the residue of injection drugs in our hospital pharmacy intravenous admixture service

作　　者：葛余敏[1] 

机构地区：[1]杭州市中医院药剂科,310007

出　　处：《中国医药》2014年第3期421-423,共3页China Medicine

摘　　要：目的 探讨影响我院注射用粉针剂药物残留量的因素及对策.方法 选取杭州市中医院110支磺苄西林粉针剂随机分成抽检组（60支）和定检组（50支）,抽取药液之后,收集残留液计算残留药物剂量.抽检组为随机科室护士操作,定检组为指定操作正规的静脉药物配制中心药师操作.比较2组每支残留均量,每组残留总量及加入不同剂量溶媒时残留量.结果 定检组每支残留均量[（0.18±0.07）ml]、每组残留总量[（1.77±0.07）ml]及加入3、4、5、6 ml溶媒时残留有效量均值[（59.0±2.3）、（44.2±1.8）、（35.4±1.4）、（29.5±1.2）mg]均低于抽检组[每支残留均量：（0.26±0.17）ml;每组残留总量：（2.54±0.38）ml;3、4、5、6 ml溶媒时残留有效量均值：（84.8±12.7）、（63.6±9.5）、（50.9±7.6）、（42.4±6.4）mg],差异均有统计学意义（均P〈0.01）.定检组中注入溶媒4、5、6 ml时,平均残留有效药量均符合〈中国药典〉规定的0.5 g以上注射用无菌粉末每支装量差异限度为±5%.结论 调配人员的规范操作对减少注射用粉针剂药物残留量、保证患者安全足量有效的用药至关重要.Objective To explore the factors and countermeasures of influencing for the injectable powder injection drug residues of our hospital. Methods Totally 110 cases sulbenicillin injection in Hangzhou Traditional Chinese Medical Hospital were selected. They were randomized into sampling group （60 cases） and test group （50 cases）. After the extracting liquor, the residual liquid was collected and residual dose was calculated. The sampling group was operated by nurses, and the test group was the specified operation of pharmacist in pharmacy intravenous admixture service （PIVAS）. Residue mean, total residue and different dose of solvent residues of two groups were compared. Results Residue mean[（0.18±0.07） ml], total residue [（1.77±0.07） ml]and remain effective dose with 3, 4, 5, 6 ml solvent [（59.0±2.3）, （44.2±1.8）, （35.4±1.4）, （29.5±1.2） mg]of test group were lower than that of sampling group [（0.26±0.17） ml, （2.54±0.38） ml, （84.8±12.7） mg, （63.6±9.5） mg, （50.9±7.6） mg, （42.4±6.4） mg], the differences were statistically significant （P〈0.01）. The 4, 5, 6 ml solvent were injected into the test group, the average remain effective dose were conform to with ±5% of differences limit of above 0.5 g sterile powder injection from Chinese pharmacopoeia. Conclusion Standard operation of personnel is crucial to reduce the injectable powder injection drug residues.

关 键 词：注射用粉针剂 药物残留量 药物有效成分 

分 类 号：R472[医药卫生—护理学]