药物性肝损伤临床调查及影响因素分析  

Clinical investigation of drug induced liver injury and its influencing factors analysis

作　　者：许雪飞[1,2] 王菲[1,2] 刘芬[1,2] 张心瞳 彭文兴[1] 

机构地区：[1]中南大学,湘雅二医院,临床药学研究所,长沙410011 [2]中南大学,药学院,长沙410013

出　　处：《中国临床药理学杂志》2014年第3期216-218,共3页The Chinese Journal of Clinical Pharmacology

摘　　要：目的对药物性肝损伤(DILI)的临床特点进行总结归纳并分析其影响因素。方法对近2年DILI患者的临床资料进行回顾性分析。结果 DILI患者以男性较多(54%),用药以中药、抗结核药及联合用药居多。急性DILI中位发病时间为13 d,因药物种类而异,常见的临床症状有黄疸、乏力、纳差等。年龄、性别对其分型及预后无影响(P>0.05),分型以及起病时肝功能指标对DILI预后有明显影响(P<0.05)。结论 DILI目前尚无特异性临床症状,其预后与分型及起病时肝功能指标呈显著相关性。Objective To summarize the clinical characteristics of drug-induced liver injury（DILI） and to analyze its influencing factors. Methods Common DILI diagnosis standard of our country was used to analyze the clinical data of hospitalized DILI patients in recent two years. Results One hundred and fifty patients with DILI were enrolled： male 83（53.55%）, and traditional Chinese medicines and anti-tuberculosis drugs and drugs combination account for the major part of medication.The median onset time of DILI was the 13 d, which varied with drug species. Jaundice （60.65%） was the most common presenting symptom, and followed by anorexia（53.20%） ,weak（46.79%）, nausea（20.51%）, fever（20.51%）.Age, and gender had no effects on DILI classification and prognosis（P＞0.05）. While there were significant differences in the relation between indexes of liver function and DILI classification with prognosis（P＜0.05）.Conclusion DILI has no specific clinical symptom, and its classification and indexes of liver function have effects on the prognosis of DILI.

关 键 词：药物性肝损伤 临床特点 影响因素 回顾性分析 

分 类 号：R969.3[医药卫生—药理学] R575[医药卫生—药学]