缺氧诱导因子-1在妊娠期高血压疾病发病中的作用  

Effect of HIF-1 on hypertensive disorder complicating pregnancy

作　　者：朱雅文 耿正惠[2] 

机构地区：[1]郑州陇海医院妇产科,450053 [2]郑州大学第二附属医院妇产科

出　　处：《中国实用医刊》2014年第7期22-23,共2页Chinese Journal of Practical Medicine

摘　　要：目的探讨缺氧诱导因子-1（HIF-1）在胎盘中表达的升高及其所诱发的血管内皮损伤在妊娠期高血压疾病发病中的作用机制。方法采用免疫组化法检测妊娠期高血压疾病患者和正常晚孕妇女胎盘组织中H1F-1和可溶性血管内皮生长因子受体-1（sFlt-1）的表达，放射免疫法检测母血中内皮素（ET-1）的含量。结果妊娠期高血压疾病组胎盘中HIF-1和sFlt-1的表达以及母血ET-1水平均较正常晚孕组升高。结论HIF-1在胎盘组织中表达的升高及其所诱发的血管内皮损伤在妊娠期高血压疾病发病中起重要作用。Objective To investigate the role of elevated HIF-1 levels in placenta and the vascu- lar endothelial injury in the pathogenic mechanism of hypertensive disorder complicating pregnancy. Methods The levels of HIF-1 and sFh-1 expression in placenta were detected by immunohistochemis- try, and the maternal blood level of ET-1 was measured by radioimmunoassay. Results Compared with normal group, the levels of HIF-1 and sFlt-1 expression in placenta, the blood level of ET-1 in hyperten- sive disorder complicating pregnancy group all increased significantly. Conclusions The elevated HIF-1 expression levels in placenta and the induced vascular endothelial play aninjury important role in hyper- tensive disorder complicating pregnancy.

关 键 词：妊娠期高血压疾病 胎盘 缺氧诱导因子-1 

分 类 号：R714.246[医药卫生—妇产科学]