复方血栓通胶囊基于原料药材与药效相关联的组方规律研究  

Composition Principles of Compound Xueshuantong Capsule Based on Grey Relational Analysis Between the Four Herbs and Efficacy

作　　者：刘宏[1] 谢称石 王永刚[1] 李沛波[1] 彭维[1] 龙超峰 苏薇薇[1] 

机构地区：[1]中山大学生命科学学院,广东广州510275 [2]广东众生药业股份有限公司,广东东莞523325

出　　处：《中山大学学报（自然科学版）》2014年第2期108-113,120,共7页Acta Scientiarum Naturalium Universitatis Sunyatseni

基　　金：国家"重大新药创制"科技重大专项资助项目(2011ZX09201-201-22);国家科技支撑计划课题资助项目(2012BAT29B09);东莞医疗卫生单位科技计划资助项目(2012105102004)

摘　　要：基于灰色关联分析方法,研究复方血栓通胶囊组方中各味药材与药效间的关联性,科学解释其组方配伍规律。在复方血栓通胶囊原有配方比例的基础上,利用均匀设计调整组方中各味药材含量比例,获得复方血栓通差异样品;并进行动物药效实验考察诸差异样品活血化瘀的药效,获得其药效学数据。在此基础上运用灰色关联分析方法,分析差异样品与药效的关联性。研究表明:三七为复方血栓通活血化瘀药效的主要贡献者,对改善微循环障碍、调节凝血功能、缓解毛细血管及微小静脉堵塞起到重要作用;黄芪、丹参、玄参三味药材可显著降低血液中红细胞间的聚集性,从而使血液运行顺畅,防止血液高凝状态出现。四味药材作用各有特点又相互补充,合理发挥了其多靶点、多途径的调控作用。The present study was designed to reveal the composition principles of four herbs in compound xueshuantong capsule （CXC）based on grey relational analysis approach.According to uniform design, CXC samples with different proportions of the four herbs were prepared on the premise of the original for-mula proportion.Efficacy experiments on animals were conducted to evaluate the CXC samples effects of promoting blood circulation and removing blood stasis.Grey relational analysis approach was used to ana-lyze the relevance between CXC samples and efficacy.The results demonstrated that Panax notoginseng was the key herb performing an obviously higher efficacy contribution in CXC.It could significantly regu-late blood clotting activity,improve microcirculation and alleviate the blocking in the capillaries and small veins.Meanwhile,Radix astragali,Salvia miltiorrhizae and Radix scrophulariaceae could significantly re-duce the aggregation between red blood cells,resulting in smooth blood flow and prevention of blood hy-percoagulable state.Therefore,four herbs together could influence different aspects of blood system, which fully embodies the multi-component and multi-target peculiarities of CXC.

关 键 词：复方血栓通胶囊 药效 灰色关联分析 组方配伍规律 

分 类 号：R96[医药卫生—药理学]