补阳还五汤预处理对MIRI兔的保护作用  

Protection of MIRI Rabbits by BuYang HuanWuTang

作　　者：李淑贞[1] 杨晓晖[1] 顾宇[1] 张兰兰[1] 

机构地区：[1]沧州医学高等专科学校,河北沧州061001

出　　处：《西部中医药》2014年第3期19-21,共3页Western Journal of Traditional Chinese Medicine

基　　金：河北省科学技术研究与发展指导计划项目(编号07276466)

摘　　要：目的:观察补阳还五汤对MIRI兔心功能及血清NO的影响,探讨补阳还五汤对MIRI的保护作用及可能机制。方法:将24只家兔随机分为假手术组、模型组、补阳还五汤组各8只。分别预处理1周后,结扎左冠状动脉前降支建立MIRI模型。运用BL-420生物机能实验系统,动态监测各组兔心电图的变化,测定不同时间点各组兔左心室功能指标数值和血清中NO含量。结果:与模型组比较,结扎冠状动脉及再灌注过程中补阳还五汤组ST段上抬幅度明显降低(P<0.01),LVSP、+dp/dt、-dp/dt的数值明显升高,NO含量明显增加(P<0.01)。结论:补阳还五汤可能通过提高血清中NO的含量来改善心功能,减轻心肌缺血再灌注损伤。Objective：To explore the protection ofBuYang HuanWu Tang againstMIRI and its mechanism by observing the effects of BuYang HuanWu Tang on heart function and serum NO of MIRI rabbits.Methods： All 24 rabbits were random ized into sham operation group, model group and BuYang HuanWu Tang group, eight rabbits each group.In one week after pretreatm ent,the models were established by ligation of leftanterior descending coronary artery.ECG changes of the rabbits in differentgroups were monitored dynam ically by BL-420E ,the indexes of left ventricular function and the contents of NO in the serum were detected at different tim es. Results： Compared with the modelgroup,ST elevation ranges of BuYang HuanWu Tang group were obviously decreased in the course ofcoronary artery ligation and ischem ia-reperfusion （P＆lt;0.01）,the indexes of LVSP,＋dp/dtand -dp/dtwere raised, and the contents of NO were increased significantly （P＆lt;0.01）.C onclusion：BuYang HuanWu Tang could improve heartfunction and reduce myocardialischemic reperfusion injury by improving the contents of NO in the serum .

关 键 词：缺血再灌注 一氧化氮 心功能 补阳还五汤 

分 类 号：R256[医药卫生—中医内科学]