卟啉类化合物与DNA相互作用的研究手段进展  

The Progress of Research Methods Porphyrins Interact with DNA

作　　者：李全文 杨日威 

机构地区：[1]中山市东区卫生和计划生育局,广东中山528400

出　　处：《广东化工》2014年第5期121-122,共2页Guangdong Chemical Industry

摘　　要：卟啉是一种具有共轭大环结构的化合物,自水溶性(4-四甲基吡啶)卟啉(TMPyP)被证实能嵌入DNA的碱基对之间以来,卟啉与各种DNA以及其它生物大分子作用的研究一直倍受关注。卟啉类化合物及其金属衍生物与DNA相互作用的主要研究手段有紫外可见光谱、荧光光谱、圆二色谱、拉曼光谱、室温磷光光谱和核磁共振谱等,文章对这些研究手段的进展情况作了综述。Porphyrins are compound having the conjugated macrocyclic structure. Since water-soluble - porphyrin （TMPyP）was confirmed can be embedded between the base pairs of DNA, the interaction of porphyrin with various DNA and other biological macromolecules has been attracting much attention. The main research method of porphyrins, metallorphrins and the interaction of DNA with UV-visible spectroscopy, fluorescence spectra, circular two chromatography, Raman spectra, nuclear magnetic resonance spectroscopy and room temperature phosphorescence spectra, the progress of these research methods are summarized.

关 键 词：卟啉 DNA 研究手段 

分 类 号：TQ[化学工程]