甲基强的松龙冲击治疗难治性肾病综合征疗效分析  

ANALYSIS OF THE CURATIVE EFFECT OF METHYLPREDNISOLONE ICTUS THERAPY FOR REFRACTORY NEPHROTIC SYNDROME

作　　者：李波[1] 冯慕仁[1] 何岳林[2] 

机构地区：[1]贵州省遵义医院儿科,563002 [2]广州南方医院儿科

出　　处：《中国煤炭工业医学杂志》2000年第9期937-939,共3页Chinese Journal of Coal Industry Medicine

摘　　要：目的　探讨甲基强的松龙冲击疗法对难治性肾病综合征的疗效。方法　选择 38例难治性肾病综合征患儿 ,给予甲基强的松龙每次 2 0～ 30 mg/kg,加入 1 0 %葡萄糖溶液 1 0 0 ml中静滴 ,1 /d,连用 3d,第 4～ 7d口服强的松 2 m g/( kg· d)。未完全缓解者重复第二疗程。结果　冲击治疗后 ,血浆白蛋白有不同程度的升高 ,2 4 h尿蛋白定量、血胆固醇、血肌酐 ( Cr)、尿素氮 ( BU N)有明显降低 ,冲击治疗前后相差有高度显著性 ( P<0 .0 1 )。随着 MP冲击疗程增加 ,完全及部分缓解例数增多。结论　甲基强的松龙冲击疗法可以使难治性肾病达到较稳定的缓解及保护肾功能 ,尤其对早期病例效果较好 ,但必须通过前瞻性对照研究加以证实。Objective To study the effects of methylprednisolone (MP) pulse therapy on refractory nephrotic syndrome. Methods 38 cases of refractory nephrotic syndrome were selected for the study and 20~30mg/kg of MP added into 100ml of glucose solution (10%) was dripped intravenously once a day for 3 consecutive days followed by oral cortisol 2mg/(kg·d) for 4 days. Those who didn't responded with complete remission were treated again. Results After MP pulse therapy, plasma albumim was increased to different degrees, while 24h urine protein, serum cholesterol level, SCR and BUN determination was obviously decreased. The effects before and after the therapy were significantly different (P<0.01). Conclusion This retrospective study suggests that MP pulse therapy may induce a more stable remission of refractory nephrotic syndrome and may better protect renal function, especially if started earlier during the course of the disease. However, these results must be confirmed by a prospective controlled trial.

关 键 词：肾病综合征 甲基强的松龙 冲击治疗 疗效 

分 类 号：R692.05[医药卫生—泌尿科学] R977.11[医药卫生—外科学]