血清降钙素原在慢性阻塞性肺疾病急性发作期的临床应用价值  

Clinical value of serum procalcitonin in the guidance for antibiotic application in patients with acute exacerbation of chronic obstructive pulmonary disease

作　　者：黄燕华[1] 孙斌贝 殷小伟[1] 李晓霞[1] 张倩[1] 

机构地区：[1]江苏省常州市第二人民医院呼吸内科,江苏常州213000

出　　处：《实用临床医药杂志》2014年第1期109-110,112,共3页Journal of Clinical Medicine in Practice

摘　　要：目的探讨血清降钙素原(PCT)水平在慢性阻塞性肺疾病急性发作(AECOPD)时抗生素应用中的临床指导价值。方法将本院2012年7—12月收治的278例AECOPD患者随机分为PCT组(n=130)和常规治疗组(n=148),比较2组患者的白细胞计数(WBC)、痰细菌定量培养、住院时间及临床有效率等指标。结果 PCT组与常规治疗组的临床有效率分别为86.9%和85.3%,差异无统计学意义(P>0.05);治疗后,2组血液炎性指标白细胞计数、CRP等无显著差异,但PCT组住院时间显著短于常规治疗组。结论根据PCT水平指导抗感染治疗可以减少AECOPD患者抗生素的使用量,缩短平均住院时间。Objective To explore the clinical value of serum procalcitonin（PCT）level in the guidance for antibiotic application in patients with acute exacerbation of chronic obstructive pulmonary disease（AECOPD）. Methods 278 patients with AECOPD from July 2012 to December2012 were randomly divided into PCTgroup（n= 130）and the conventional treatment group（n=148）. Indexes such as WBC, sputum bacterial quantitative culture, duration of hospitalization and clinical effective rate were compared between the two groups. Results The clinical effective rate in the PCT group was 86.9%, and it was 85.3% in the conventional treatment group. There was no significant difference between two groups（P 0.05）. After treatment, there were no significant differences of WBC and CRP between the two groups, but duration of hospitalization in the PCT group was significantly shorter than the conventional treatment group. Conclusion According to PCT level, the antibiotic use can be adjusted to the anti- inflammatory treatment for patients with AECOPD, and the duration of hospitalization can be shortened.

关 键 词：血清降钙素原 慢性阻塞性肺疾病急性发作期 应用价值 

分 类 号：R563[医药卫生—呼吸系统]