糖尿病合并非ST段抬高急性冠脉综合征患者糖化血红蛋白与GRACE评分相关临床观察  

Clinical observation on correlation of serum level of HbA1c and GRACE risk score in patients with non-ST segment elevation acute coronary syndrome and type 2 diabetes

作　　者：林敏瑜[1] 刘菁[1] 余碧菁[1] 

机构地区：[1]厦门大学附属福州第二医院心内科,350007

出　　处：《中国现代药物应用》2014年第6期1-2,共2页Chinese Journal of Modern Drug Application

摘　　要：目的观察2型糖尿病合并非ST段抬高急性冠脉综合征(NSTE-ACS)患者糖化血红蛋白(HbA1c)水平与全球急性冠脉事件注册(GRACE)危险评分的相关性。方法 67例非ST段抬高急性冠脉综合征合并糖尿病均行经冠状动脉造影确诊,同时选择单纯NSTE-ACS患者67例作为对照组。测定HbA1c水平,比较NSTE-ACS合并2型糖尿病患者GRACE危险评分与HbA1c水平相关性。结果血清HbA1c水平与GRACE危险评分呈正相关,高危组患者的血清HbA1c水平明显高于中、低危组,高血清HbA1c水平NSTE-ACS患者的GRACE危险评分也高于低血清HbA1c水平患者,差异均有统计学意义(P<0.01)。结论血清HbA1c水平对NSTE-ACS合并2型糖尿病患者预后评估与GRACE危险评分具有临床一致性。Objective To investigate correlation of serum level of HbA1c and GRACE risk score in patients with non-ST segment elevation acute coronary syndrome （NSTE-ACS） and type 2 diabetes. Methods All of 134 patients undergoing coronary angiography（CAG）, 67 patients were diagnosed with type 2 diabetes and NSTE-ACS, the other 67 patients with NSTE-ACS cases were served as control. The serum level of HbA1c was measured in peripheral venous blood by in all the patients, and the GRACE risk score were assessed in patients with type 2 diabetes. The serum level of HbA1c and GRACE risk score were analyzed by Spearman rank correlation. Results The serum level of HbA1c was significantly higher in patients with Type 2 diabetes and NSTE-ACS than the control （all P〈0.01）. The serum level of HbA1c in patients with NSTE-ACS were positively correlated with GRACE risk score （r=0.503, P=0.001）. Conclusion The serum level of HbA1c has a good consistency with GRACE risk score in NSTE-ACS patients with type 2 diabetes.

关 键 词：2型糖尿病 急性冠脉综合征 糖化血红蛋白 全球急性冠脉事件注册危险评分 

分 类 号：R541.4[医药卫生—心血管疾病]