肝胆清片对ConA诱导小鼠肝损伤保护作用的研究  

The Protective Effect of Gandanqing Tablet in ConA-induced Liver Injury of Mice

作　　者：陶元明 王晓磊 苏恺琪 唐俊 葛海涛 

机构地区：[1]江苏黄河药业股份有限公司,江苏阜宁224400

出　　处：《中外医学研究》2014年第9期140-141,共2页CHINESE AND FOREIGN MEDICAL RESEARCH

摘　　要：目的:观察肝胆清片对肝损伤小鼠(ConA诱导)的保护作用。方法:通过测定血清丙氨酸转氨酶(ALT)、谷草转氨酶(AST)以及肿瘤坏死因子-α(TNF-α)、肝匀浆超氧化物歧化酶(SOD)、丙二醛(MDA)等数值,研究肝胆清片对小鼠肝脏的保护作用。结果:肝胆清片高剂量组能够明显降低肝损伤小鼠模型(ConA诱导)的血清ALT、AST、TNF-α、肝匀浆MDA,提高肝匀浆SOD(P<0.01)。结论:肝胆清片对ConA诱导肝损伤小鼠具有一定的保护作用。Objective：To study the protective effect of Gandanqing tablet in ConA-induced liver injury of mice.Method：The serum ALT,AST,TNF-αand liver homogenate SOD and MDA were determined to evaluate its protective effects on the liver.Result：Gandanqing Tablet high-dose group was significantly reduced ConA-induced liver injury in mice models of serum ALT,AST,TNF-αand liver homogenate MDA,increased liver homogenate SOD（P〈0.01）. Conclusion：Gandanqing tablet has protective effect on ConA-induced liver injury in mice.

关 键 词：肝胆清片 肝损伤 

分 类 号：R285.5[医药卫生—中药学]