产黄青霉菌高能电子诱变选育  

Breeding of Penicillium Chrysogenum Strain by High Energy Electrons Mutation

作　　者：王成 张军剪 尹贵超 

机构地区：[1]华北制药河北华民药业有限责任公司倍达工厂,河北石家庄052165

出　　处：《煤炭与化工》2014年第2期68-69,73,共3页Coal and Chemical Industry

摘　　要：为了选育出青霉素高产菌株,以产黄青霉菌10-2-12为出发菌株,经高能电子诱变后分离。经过18批次筛选得到的突变株13-6-55效价比出发株高8.2%,且菌丝状态、传代稳定性好。在试验罐上的平均发酵单位比对照高3.6%。In order to breed the penicillin high producing strain, the PeniciUium Chrysogenum 10-2-12 was adopted to mutate by high energy electrons mutation. The mutant 13-6-55 was screened through 18 batches, the titer of the mutant 13-6-55 was 8.2% higher than the titer of the Penieillium Chrysogenum 10-2-12, and the genetic stabilization of the mutant 13-6-55 was fine. The average titer in fermentor was increased 3.6%.

关 键 词：产黄青霉菌 菌株高能电子诱变 苯乙酸钠 

分 类 号：R978[医药卫生—药品]