长期口服阿卡波糖对SAMP8小鼠背海马synaptotagmin Ⅰ的影响  

Effects of orally chronic administration of acarbose on synaptotagmin Ⅰ level in dorsal hippocampus of the SAMP8 mice

作　　者：随旭 陶飞[1] 童晶晶[1] 陈贵海[1] 

机构地区：[1]安徽医科大学第一附属医院神经内科,合肥230022

出　　处：《安徽农业大学学报》2014年第2期287-289,共3页Journal of Anhui Agricultural University

基　　金：国家自然科学基金(30872730;81370444);安徽省高校省级自然科学重点项目(ZD2008007-1)共同资助

摘　　要：利用免疫组化法检测长期口服阿卡波糖对SAMP8小鼠背海马突触蛋白synaptotagminⅠ(SytⅠ)表达的影响。结果显示,SytⅠ在背海马CA1、CA3区和齿状回各层均有表达。老年对照组小鼠背海马各区SytⅠ的相对含量显著高于青年对照组(Ps<0.05)。阿卡波糖处理组小鼠背海马各区SytⅠ的相对含量显著低于同龄对照组(Ps<0.05)。上述结果提示长期口服阿卡波糖可减轻SAMP8小鼠背海马年龄相关性SytⅠ增加的水平。In this study, the effect of orally chronic administration of acarbose on synaptotagmin I （Syt I） level in dorsal hippocampus of the SAMP8 mice was explored using immunohistochemical method. The results indicated that Syt I was expressed in CA1 and CA3 subfields and dentate gyrus of the dorsal hippocampus： The relative amount of Syt I in the elderly control group was significantly higher than that in the young control group in each subfields of the dorsal hippocampus （Ps〈0.05）. However, the acarbose-treated mice had significantly lower level of Syt I in all subfields in comparison with the elderly control mice （Ps〈0.05）. Our results suggest that orally chronic administration of acarbose could reduce the age-related increase of Syt I in the dorsal hippocampus of the SAMP8 mice.

关 键 词：衰老 阿卡波糖 海马 小鼠 SYNAPTOTAGMIN 

分 类 号：S865.13[农业科学—野生动物驯养] R339.38[农业科学—畜牧兽医]