以碳酸钾为高效非均相催化剂合成2-氨基-3-氰基-4,5,6,7-四氢苯并[b]噻吩  

Synthesis of 2-Amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carbonitrile with Potassium Carbonate as A High-Efficient Heterogeneous Catalyst

作　　者：谭小红[1,2] 杨平[2] 宋新建[1,2] 

机构地区：[1]湖北民族学院科技学院,湖北恩施445000 [2]湖北民族学院化学与环境工程学院,湖北恩施445000

出　　处：《化学与生物工程》2014年第3期24-27,共4页Chemistry & Bioengineering

基　　金：国家自然科学基金资助项目(201262012);湖北省教育厅科研项目(B20101901)

摘　　要：提出了一种以碳酸钾为非均相固体碱催化剂的通过三组分Gewald反应一锅法简易高效合成2-氨基-3-氰基-4,5,6,7-四氢苯并[b]噻吩的新方法。考察了催化剂用量、反应时间和溶剂类型对目标产物收率的影响,确定最佳反应条件如下:催化剂用量为20%(摩尔分数),反应时间为3.0h,溶剂为乙醇。该方法具有催化剂价廉高效、分离纯化简单、反应时间短以及产物收率高等优点。A facile and high-efficient one-pot procedure for synthesis of 2-amino-4,5,6,7-tetrahydrobenzo [b]thiophene-3-carbonitrile via Gewald＇s three-component reaction with potassium carbonate as a heterogeneous solid base catalyst has been developed.The effects of catalyst dosage,reaction time and solvent type on the product yield are studied.The optimum reaction conditions are identified as follows：the catalyst dosage is 20％ （molar fraction）,the reaction time is 3.0 h and the solvent is ethanol.This method has advantages of cheap and high-efficient catalyst,simple purification,short reaction time and high product yield.

关 键 词：Gewald反应 2-氨基-3-氰基-4 5 6 7-四氢苯并[b]噻吩 2-氨基噻吩 非均相催化剂 碳酸钾 一锅法 

分 类 号：O626.12[理学—有机化学]