对氯苯乙酸的合成  

Synthesis of p-Chlorophenylacetate Acid

作　　者：邹晓虹 聂少春 毛利民 郭涛 李毅 

机构地区：[1]武汉有机实业有限公司,湖北武汉430035

出　　处：《化学与生物工程》2014年第3期66-67,共2页Chemistry & Bioengineering

摘　　要：以对氯苯乙腈为原料直接经硫酸催化水解合成对氯苯乙酸,通过对传统工艺的重新设计,得到了适合工业化的新工艺,优化的合成条件为：硫酸质量分数60％～70％、反应时间3h、反应温度130～140℃,对氯笨乙酸收率达95％左右.p-Chlorophenylacetate acid was prepared by hydrolysis from p-chlorobenzyl cyanide catalyzed by sulfuric acid.By redesigning the traditional method,the process suitable for industrial manufacture was obtained,the optimal synthetic conditions were as follows：mass fraction of sulfuric acid of 60 ％ ～ 70 ％,reaction time of 3 h,reaction temperature of 130 ～ 140 ℃,and the yield of p-chlorophenylacetate acid reached about 95％.

关 键 词：对氯苯乙腈 对氯苯乙酸 水解 

分 类 号：O624.12[理学—有机化学]