二阶导数光谱法测定溴新斯的明缓释固体分散体中药物的含量  

Determination of content of neostigmine bromide in sustained-release solid dispersion by second derivative spectrometry

作　　者：万坤[1] 孙立力[1] 胡江波[1] 张景勍[1] 

机构地区：[1]重庆医科大学高校药物工程研究中心,重庆400016

出　　处：《中国医院药学杂志》2014年第6期496-498,共3页Chinese Journal of Hospital Pharmacy

摘　　要：目的：测定溴新斯的明缓释固体中药物的含量。方法：采用二阶导数光谱法，以263．3nm处峰值为定量依据，消除制剂中其他成分对测定的干扰，测定溴新斯的明缓释固体分散体中药物的含量。结果：溴新斯的明在0．1～0．4mg·ml“范围内浓度与263．3nm处峰值具有良好的线性关系，回归方程为：Y=1．0877X-0．0417（r=0．9992）；平均回收率为99．99％。RSD为0．49％（n=9）。结论：本方法操作简单，且稳定性、准确度和精密度均符合要求，可用于溴新斯的明缓释固体分散体中溴新斯的明含量的测定。OBJECTIVE To determine the content of neostigmine bromide in sustained-release solid. METHODS The contents of neostigmine bromide in sustained-release solid dispersion were determined by second derivative spectrometry in which the quantitative calculations were based on the peak at 263.3 nm,to remove the influence of other composition. RESULTS The experiment had a good liner relationship range from 0. 1 to 0. 4 mg-mi-1 for neostigmine bromide content. The regression equa- tion was Y = 1. 087 7X - 0. 041 7 （r = 0. 999 2） ; the average recovery rate was 99. 99%, RSD was 0. 49% （n = 9）. CONCLU- SION The method was simple,accurate and rapid. It is suitable for the determination of neostigmine bromide in sustained-re lease solid dispersion.

关 键 词：溴新斯的明 缓释固体分散体 二阶导数光谱法 含量测定 

分 类 号：R927.2[医药卫生—药学]