注射用甲泼尼龙琥珀酸钠与5%转化糖注射液配伍稳定性考察  

Compatible Stability of Methylprednisolone Sodium Succinate for Injection in 5% Invert Sugar Injection

作　　者：黎明[1] 程道海[1] 黄振光[1] 陈雯玲[2] 陆华[1] 

机构地区：[1]广西医科大学第一附属医院药学部,南宁530021 [2]广西医科大学药学院,南宁530021

出　　处：《中国药房》2014年第14期1288-1290,共3页China Pharmacy

摘　　要：目的:考察注射用甲泼尼龙琥珀酸钠与5%转化糖注射液的配伍稳定性。方法:于室温不避光条件下,将注射用甲泼尼龙琥珀酸钠40 mg加入5%转化糖注射液250 ml中,3 h内观察配伍液外观及测定pH值变化,并采用高效液相色谱法测定甲泼尼龙琥珀酸钠的含量。结果:配伍液的外观澄清,pH值及甲泼尼龙琥珀酸钠的含量均无明显变化。结论:注射用甲泼尼龙琥珀酸钠40 mg与5%转化糖注射液250 ml配伍在3 h内稳定。OBJECTIVE： To investigate the compatible stability of Methylprednisolone sodium succinate for injection in 5% Invert sugar injection. METHODS： At the room temperature and under light condition, 40 mg Methylprednisolone sodium succi- nate for injection was added into 5% Invert sugar injection 250 ml; the appearance of the mixed solution was observed, and pH value was detected in 3 hours; at the same time, the content of methylprednisolone sodium succinate was determined by HPLC. RESULTS ： There were no significant changes in appearance and pH value of mixed solution, and content of methylprednisolone sodium succinate. CONCLUSIONS： Methylprednisolone sodium succinate for injection （40 mg） can be compatible with 5% In- vert sugar injection （250 ml） in 3 hours.

关 键 词：注射用甲泼尼龙琥珀酸钠 转化糖注射液 配伍稳定性 高效液相色谱法 

分 类 号：R969.2[医药卫生—药理学] R979.5[医药卫生—药学]