超敏C反应蛋白与维吾尔族老年单纯收缩期高血压患者血管内皮功能的相关性  

Correlation between high-sensitivity C-reactive protein and vascular endothelial function in Uygur elderly patients with isolated systolic hypertension

作　　者：刘忠玉[1] 李辰[2] 黄榕[3] 周亚丽[3] 张艳君[4] 赵宗峰[4] 

机构地区：[1]安徽医科大学新疆临床学院,乌鲁木齐830001 [2]石河子大学医学院,石河子832000 [3]新疆维吾尔自治区人民医院干部保健二科,乌鲁木齐830001 [4]新疆维吾尔自治区人民医院临床中心实验室,乌鲁木齐830001

出　　处：《安徽医科大学学报》2014年第3期338-342,共5页Acta Universitatis Medicinalis Anhui

基　　金：新疆维吾尔自治区自然科学基金(编号:2011211A053);新疆维吾尔自治区人民医院院内资助项目(编号:20090108)

摘　　要：目的探讨超敏C反应蛋白(hs-CRP)与维吾尔族老年单纯收缩期高血压(ISH)患者血管内皮功能之间的关系。方法选取维吾尔族老年ISH患者100例作为ISH组,维吾尔族老年原发性高血压(EH)患者100例作为EH组,并选择年龄与之相匹配的维吾尔族血压正常人群(NT)80例作为NT组。采用免疫透射比浊法测定血清hs-CRP水平、ELISA法测定血清内皮素1(ET-1)浓度,Griess法测定血清一氧化氮(NO)含量;运用超声技术测定血流介导的内皮依赖性血管舒张功能(FMD),动脉硬化检测仪测定颈-股动脉脉搏波传导速度(cfPWV)。采用直线相关分析及多元线性逐步回归分析法分析hs-CRP与ET-1、cfPWV、NO、FMD的相关性。结果与NT组比较,ISH组、EH组hs-CRP、cfPWV、ET-1明显升高(P<0.01),而NO、FMD明显降低(P<0.01);ISH组hs-CRP、cfPWV、ET-1高于EH组(P<0.01);ISH、EH两组间的NO、FMD差异无统计学意义。相关性分析表明,hs-CRP与ET-1、cfPWV呈正相关(P<0.01),与NO、FMD呈负相关(P<0.01)。多元线性逐步回归分析显示hs-CRP、NO、ET-1、cfPWV是影响FMD的主要因素(P<0.05)。结论维吾尔族老年ISH患者血清hs-CRP水平明显升高,且与FMD呈负相关。Objective To investigate the relationship between high-sensitivity C-reactive protein （ hs-CRP ） and vascular endothelial function of Uygur elderly patients with isolated systolic hypertension （ ISH ） . Methods 100 Uygur old patients with isolated systolic hypertension （ ISH） were enrolled as ISH group, recrutied pairs of essential hypertension （ EH） 100 cases as the EH group,another 80 age-matched normotension（ NT） people were chosen as NT group. Serum high-sensitivity C-reactive protein （hs-CRP） and endothelin-1 （ET-1） concentration were meas-ured by turbidimetric immunoassay and ELISA method respectively. Nitric oxide （ NO） was determined by Griess method, the flow-mediated endothelium-dependent vasodilation function （ FMD） was detected through ultrasound technology,and carotid-femoral pulse wave conduction velocity （ cfPWV） was measured by automatic arteriosclero-sis detector. The association between hs-CRP and ET-1,cf-PWV,NO,FMD was described by linear correlation a-nalysis and multiple linear stepwise regression analysis. Results Compared with those of NT group,hs-CRP,cfP-WV,ET-1 in ISH and EH groups were higher （P〈0.01）,while the NO,FMD were lower（P〈0.01）;hs-CRP,cf-PWV,ET-1 in ISH groups were higher than EH group （P〈0.01）; the difference of NO,FMD between ISH and EH groups was not significant statistically. hs-CRP was positively correlated with ET-1 and cfPWV （ P〈0.01 ） , but was negatively correlated with NO and FMD （ P〈0.01 ） . Multiple linear stepwise regression analysis showed that hs-CRP,NO,ET-1,cfPWV were the main influencing factors of FMD（P〈0.05）. Conclusion hs-CRP level is significantly elevated in Uygur elderly patients with isolated systolic hypertension and negatively correlated with FMD.

关 键 词：维吾尔族 单纯收缩期高血压 超敏C反应蛋白 血流介导的内皮赖性血管舒张功能 脉搏波传导速度 

分 类 号：R544.1[医药卫生—心血管疾病]