利伐沙班与低分子肝素预防人工全髋关节置换术后深静脉血栓效果比较  

Rivaroxaban versus low molecular weight heparin to prevent deep venous thrombosis following total hip arthroplasty:Comparative study

作　　者：高玉镭 林木良 王东辰 崔存宝 郑肖 田敏[1] 

机构地区：[1]解放军88医院全军骨科中心,山东泰安271000 [2]解放军359医院骨科,江苏镇江212000

出　　处：《实用医药杂志》2014年第3期205-207,共3页Practical Journal of Medicine & Pharmacy

摘　　要：目的 观察利伐沙班与低分子肝素在预防人工全髋关节置换深静脉血栓的疗效和安全性.方法2009年02月-2011年05月行人工全髋关节置换术的患者200例分为两组：利伐沙班组100例,术前6～8 h给予利伐沙班10 mg口服,1次/d,连续14 d;低分子肝素组100例,术后给予低分子肝素5000 U,1次/d皮下注射,连续14 d.术后14 d行双下肢静脉彩超检查有无深静脉血栓形成,并观察两组用药期间有无肺动脉栓塞和严重出血事件的发生.结果利伐沙班组深静脉血栓形成的发生率6%,显著低于低分子肝素组10%（P＜0.05）,两组均未发生肺动脉栓塞和严重出血事件.结论利伐沙班较低分子肝素能更有效预防髋关节置换术后下肢深静脉血栓的形成.二者均较安全.Objective To observe and compare the clinical effects and security of low molecular weight heparin and rivaroxaban against deep venous thrombosis （DVT） after total knee arthroplasty（THA）. Methods Totally 200 THA patients to be received THA from May 2009 to February 2011 were randomized into two groups：rivaroxaban group（100 cases） and low molecular weight heparin group （100 cases）. Rivaroxaban group was treated with rivaroxaban 10 mg,once a day for 14 days,6-8 h before operation,and heparin group was injected with heparin,every day for 10 days after operation. After 14 days,color ultrasonography on vein of double lower extremities was used to find out any deep vein thrombosis,and the pulmonary embolism or serious bleeding. Results The incidence rate of DVT in the rivaroxaban group was obviously lower than in the heparin group（5% vs 9%,P＜0.05）. No pulmonary embolism or serious bleeding occurred. Conclusion Rivaroxaban to prevent lower extremities DVT in patients after knee arthroplasty is better than heparin,both are safe.

关 键 词：抗凝药 关节置换 髋关节 深静脉血栓 

分 类 号：R687.4[医药卫生—骨科学]