甲状腺球蛋白基因多态性与自身免疫性甲状腺疾病易感性的meta分析  

A meta-analysis of the association between thyrogiobulin gene polymorphism and autoimmune thyroid disease

作　　者：刘佳[1] 徐援[1] 高霞[1] 姚志[1] 张鹏睿[1] 王广[1] 

机构地区：[1]首都医科大学附属北京朝阳医院内分泌科,100020

出　　处：《中华内分泌代谢杂志》2014年第3期221-224,共4页Chinese Journal of Endocrinology and Metabolism

基　　金：国家自然科学基金资助项目（81270369）

摘　　要：采用meta分析系统评价甲状腺球蛋白基因多态性与自身免疫性甲状腺疾病（AITD）易感性的关系。共纳入8项病例对照研究，E33SNP及E12SNP与亚洲人AITD的OR分别为1．54（95％CI1．21～1．97，P=0．024）及1．12（95％CI1．05～1．21，P=0．033）。甲状腺球蛋白基因多态性与AITD可能相关。The association between thyroglobulin gene polymorphism and autoimmune thyroid disease was investigated. A total of eight case-control studies were included. E33SNP was associated with increased susceptibility of autoimmune thyroid disease in recessive model（ OR= 1.54, 95% CI 1.21 ～ 1.97, P=0.024） , while E12SNP was associated with increased susceptibility of autoimmune thyroid disease in allele model （ OR = 1. 12, 95% CI 1.05 ～1.21, P = 0. 033 ）. Thyroglobulin gene polymorphism seems to be associated with autoimmune thyroid disease.

关 键 词：甲状腺球蛋白 自身免疫性甲状腺疾病 基因多态性 

分 类 号：R581[医药卫生—内分泌]