利奈唑胺新型序贯疗法治疗老年耐甲氧西林金黄色葡萄球菌肺炎的临床评价  

Clinical evaluation of new pattern-sequential treatment of linezolid on meticillin-resistant Staphylococcus aureus pneumonia in elderly patients

作　　者：汤小芳[1] 陈旭娇[1] 柴栖晨[1] 程磊[1] 

机构地区：[1]浙江医院老年病综合示范病房,浙江杭州310013

出　　处：《中国新药与临床杂志》2014年第3期230-232,共3页Chinese Journal of New Drugs and Clinical Remedies

摘　　要：目的评价利奈唑胺针剂、片剂新型序贯疗法治疗老年耐甲氧西林金黄色葡萄球菌（MRSA）肺炎的临床疗效及其安全性。方法将73例老年MRSA感染肺炎患者随机分为两组，观察组35例每日早8时予利奈唑胺针剂600mg静脉滴注，晚8时予利奈唑胺片剂600mg口服：对照组38例每日早8时及晚8时均予万古霉素针剂1．0g静脉滴注。两组疗程均10-15d。比较两组患者之间的临床疗效及不良反应。结果观察组的临床有效率为97％，对照组为82％；观察组不良反应发生率为20％，对照组为32％，组间比较均有显著差异（P〈0．05）。结论利奈唑胺针剂、片剂新型序贯疗法临床治疗安全、有效．且给药便捷，可作为老年MRSA肺炎治疗的选择。AIM To evaluate the efficacy and safety of the new pattern-sequential treatment of linezolid injection and tablet on meticillin resistant Staphylococcus aureus （MRSA） pneumonia in elderly patients. METHODS Seventy-three elderly patients with MRSA pneumonia were randomly divided into two groups. Thirty-five patients in treatment group were given intravenous drip of linezolid 600 mg at eight a.m. and orally linezolid 600 mg at eight p.m.. Thirty-eight patients in control group were given an intravenous drip of vancomycin 1.0 g at eight a.m. and at eight p.m.. Both groups were treated for 10 - 15 days. The effect and adverse reactions of the two groups were compared. RESULTS The effective rate of the treatment group and the control group was 97% and 82%, respectively （P 〈 0.05）, and the adverse reaction rate of the treatment group and the control group was 20% and 32%, respectively （P 〈 0.05）. CONCLUSION The new pattern-sequential treatment of linezolid injection and tablet is safe, effective and convenient on treatment of MRSA pneumonia, and can be used as a choice for elderly patients with MRSA pneumonia.

关 键 词：利奈唑胺 序贯治疗 肺炎 葡萄球菌 金黄色 治疗结果 

分 类 号：R961[医药卫生—药理学]