Fungal defensins, an emerging source of anti-infective drugs  

作　　者：Yucheng Wu Bin Gao Shunyi Zhu 

机构地区：[1]Group of Animal Innate Immunity, State Key Laboratory of Integrated Management of Pest Insects and Rodents, Institute of Zoology, Chinese Academy of Sciences

出　　处：《Chinese Science Bulletin》2014年第10期931-935,共5页

基　　金：supported by the National Basic Research Program of China(2010CB945300);the National Natural Science Foundation of China(31221091)

摘　　要：With the rapid increase of antibiotic-resistant pathogens and the decline of discovery and development of new antibiotics,there is an urgent need to exploit alternative anti-infective drugs.Fungal defensin-like peptides are emerging as a class of new source of anti-infective drugs due to their potent antibacterial activity,low toxicity,and high serum stability.Fungal genome sequencing projects combined with the development of recombinant expression techniques will accelerate the discovery of fungal defensinlike peptides.With the rapid increase of antibiotic-resistantpathogens and the decline of discovery and development ofnew antibiotics, there is an urgent need to exploit alterna-tive anti-infective drugs. Fungal defensin-like peptides areemerging as a class of new source of anti-infective drugsdue to their potent antibacterial activity, low toxicity, andhigh serum stability. Fungal genome sequencing projectscombined with the development of recombinant expressiontechniques will accelerate the discovery of fungal defensin-like peptides.

关 键 词：ANTIBIOTIC-RESISTANCE Micasin FUNGUS 

分 类 号：R978.1[医药卫生—药品]