马立克氏病疫苗胚胎免疫鸡红细胞免疫功能的研究  

STUDIES ON THE RED BLOOD CELL(RBC)IMMUNE FUNCTION OF PERIPHERY BLOOD OF CHICKENS WHICH EMBRYONALLY VACCINATED WITH MAREK’S DISEASE VACCINE

作　　者：鲍恩东[1] 苏建东[1] 

机构地区：[1]南京农业大学动物医学院,南京210095

出　　处：《畜牧兽医学报》2000年第5期436-440,共5页ACTA VETERINARIA ET ZOOTECHNICA SINICA

基　　金：国家自然科学基金项目 !(396 0 0 1 1 1 )

摘　　要：作者检测了胚胎免疫鸡 (孵化至 18日龄时鸡胚接种马立克氏病二价疫苗 )及其相应 1日龄免疫鸡和未免疫鸡的红细胞CR1花环率和红细胞IC花环率以观察其外周血液红细胞免疫功能。结果表明 ,随着试验鸡日龄的增长 ,其外周血液中红细胞CR1活性呈现一定的递减性变化 ,但胚胎免疫鸡红细胞CR1活性的降低幅度远低于其它两组鸡。胚免鸡出壳后 7日龄进行vMDV攻毒 ,结果也显示胚胎免疫可显著阻止红细胞免疫功能的下降。此外 ,胚免组鸡血清中红细胞免疫粘附抑制因子活性下降 (IC形成减少 ) 。The red blood cell(RBC)immune function of periphery blood of chickens which embryonally vaccinated with Marek’s disease combined vaccine(HVT+Z 4)at the 18th hatching day was studied by the methods of the RBC CR 1 rosette rate and RBC IC rosette rate.The results showed that the RBC CR 1 rosette rate of chicken periphery blood decreased regularly with the growth of age,but the decreasing degree of the RBC-CR 1 rosette rate of embryo vaccination group was much lower than that of any other groups.The result of experimental chickens challenged with vMDV at the 7th day after hatching also showed that the decreasing of the RBC immune function of embryonally vaccinated chickens could be inhibited obviously.In addition,decreasing activity of serum RBC immune adherence inhibitor(reducing of circle immune complex)also made the activity of the RBC immune function increasing more.

关 键 词：马立克氏病 胚胎 红细胞免疫 鸡 

分 类 号：S852.4[农业科学—基础兽医学] S858.315.3[农业科学—兽医学]