辛伐他汀剂量对老年高脂血症患者疗效与安全性的影响  

The efficacy and safety of different simvastatin doses on hyperlipidemia in the elderly

作　　者：刘富春[1] 王国威[1] 宋航[1] 张浩[1] 高军[1] 

机构地区：[1]解放军第324医院药剂科,重庆400020

出　　处：《重庆医学》2014年第9期1088-1089,1092,共3页Chongqing medicine

摘　　要：目的研究辛伐他汀剂量对老年高脂血症患者疗效与安全性的影响。方法选取老年高脂血症患者120例,随机分为两组,每组60例,分别给予辛伐他汀10mg/d(10mg/d剂量组)和20mg/d(20mg/d剂量组),疗程3个月。在治疗前后检测患者总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)水平,并记录疗效和不良反应。结果治疗后,两组患者TC、TG、LDL-C、HDL-C均较治疗前有所改善,差异有统计学意义(P<0.05);且20mg/d剂量组疗效优于10mg/d剂量组,差异有统计学意义(P<0.05);两组患者不良反应发生率之间的差异无统计学意义(P>0.05)。结论 20mg/d剂量辛伐他汀对老年高脂血症患者疗效更好,且同样安全可靠。Objective To study the efficacy and safety of different simvastatin doses on hyperlipidemia in the elderly .Methods 120 patients with hyperlipidemia were randomly divided into two groups ,60 cases in each group ,patients were given simvastatin 10 mg/d（10 mg/d group） or 20 mg/d（20 mg/d group） .Data were collected before and after treatment ,including total cholesterol （TC） ,three acyl glycerin （TG） ,low density lipoprotein cholesterol （LDL-C） ,high density lipoprotein cholesterol （HDL-C） ,treat-ment efficacy and adverse reactions events .Results 3 month after treatment ,TC ,TG ,LDL-C and HDL-C were better than before treatment in both groups（P＆lt;0 .05）;and the curative effect in 20 mg/d group was better than 10 mg/d group（P＆lt;0 .05） .There was no significant difference in incidence of adverse reactions events between the two groups （P＆gt;0 .05） .Conclusion 20 mg/d simvasta-tin is better than 10 mg/d simvastatin in efficacy of elderly patients with hyperlipidemia ,and offers a safe and reliable treatment .

关 键 词：高脂血症 老年人 辛伐他汀 治疗效果 

分 类 号：R589.2[医药卫生—内分泌]