MRMT-1致骨癌痛模型脊髓内TRKC表达变化  

Change of TRKC Expression in Spinal Cord Bone Cancer Model Induced by MRMT-1

作　　者：孟馥芬[1] 刘宏宇 徐杨[3] 刘亚华[1] 王廷华[3] 

机构地区：[1]新疆医科大学附属肿瘤医院麻醉科,新疆乌鲁木齐830000 [2]新疆职业病医院麻醉科,新疆乌鲁木齐830000 [3]四川大学华西医院转化神经科学中心,成都成都610041

出　　处：《新疆医学》2014年第1期12-16,共5页Xinjiang Medical Journal

基　　金：新疆维吾尔自治区科技厅青年自然科学基金;项目编号:2010211B13

摘　　要：目的:研究TRKC在MRMT-1骨癌痛模型的表达变化。方法:利用MRMT-1细胞胫骨注射复制骨癌痛大鼠模型,同时设立正常组做对照。术后28 d活取脊髓腰膨大采用Real Time PCR检测TRKC表达量,并进行统计学分析。结果:正常组大鼠脊髓可见TRKC mRNA表达,骨癌痛组大鼠脊髓中TRKC mRNA表达较正常组明显下降,差异有统计学意义(P<0.05)。结论:本实验发现骨癌疼大鼠脊髓内TRKC表达明显下降,为进一步研究TRKC与疼痛的关系提供了重要依据。Objective：To investigate the expression of TRKC in cancer-induced bone pain models. Methods： Cancer-induced bone pain models were established via tibia injection of MRMT-1 cells, and normal group was designed as control. 28days after sarcoma injection, TRKC mRNA expression of lumbar enlargement of spinal cord was measured using Real Time PCR. Results：The expression of TRKC mRNA in bone cancer pain group was decreased compared with normal group（P〈0.05）. Conclusion：This study found that TRKC expression significantly decreased in the bone cancer pain models, which provides an important basis for further studying the relationship between bone pain and TRKC.

关 键 词：骨癌痛 TRKC 大鼠 脊髓 

分 类 号：R245.0[医药卫生—针灸推拿学]