PR间期延长对肥厚型梗阻性心肌病患者临床特征的影响  

The influence of PR interval prolongation on the clinical characterization in patients with hypertrophic obstructive cardiomyopathy

作　　者：杜为 李小荣 刘榜霞 满艺龙 肖峰 曹克将 汪道武 

机构地区：[1]南京医科大学第一附属医院心血管内科江苏省心肺疾病研究所,江苏南京210029

出　　处：《中国心脏起搏与心电生理杂志》2014年第1期33-36,共4页Chinese Journal of Cardiac Pacing and Electrophysiology

基　　金：国家重点基础研究发展计划(973计划)(No:2013CB531105);国家"十二五"科技支撑计划项目(No:2011BAI11B13);国家自然科学基金(No:81170159);江苏高校优势学科建设工程;江苏省心血管病临床医学研究中心项目(No:BL2012011);江苏省人民医院创新团队基金(编号:IRT-014)

摘　　要：目的探讨肥厚型梗阻性心肌病(HOCM)患者PR间期与临床特征的关系。方法收集分析本院HOCM患者74例,根据PR间期将患者分为:A组(PR>200 ms,n=17)和B组(120 ms≤PR≤200 ms,n=57)。比较两组间的临床特征以及超声心动图指标,并通过相关性分析探讨PR间期与超声心动图指标之间的关系。结果两组患者在心功能、临床症状及治疗方面无差异,但A组的临床症状略为严重。相关性分析显示PR间期与左室内径呈正相关(P<0.01),与左室射血分数、短轴缩短率、左室流出道压力阶差呈负相关(P<0.05)。结论 PR间期与心脏结构性功能参数相关,PR间期延长的HOCM患者的临床症状较为严重。Objective To study the relationship between PR interval and the clinical characterizations in patients with hypertrophic obstructive cardiomyopathy （ HOCM ）. Methods Seventy-four patients with HOCM were retrospectively analyzed, which were enrolled in our hospital. All patients were divided into two groups according to PR interval ： group A ： （PR〉200 ms,n= 17） ; group B （120 ms≤PR≤200 ms,n=57）. Compared the clinical and echocardiographic features of the two groups, and correlation analysis was used to determine the association between PR interval and echocardiographic parameters. Results There were no significant differences in cardiac function, clinical symptoms, and treatment choices, but patients with PR prolongation showed more severe symptoms. The correlation analysis showed that PR interval and LVDd, LVDs showed a significant positive correlation （P〈0.01） ;PR interval and IVS, FS, LVOTPG were negatively correlated （ P〈0.05 ）. Conclusion PR interval is associated with cardiac structure and function parameters, HOCM Pa- tients with PR interval prolongation often show more severe clinical symptoms.

关 键 词：心血管病学 肥厚型梗阻性心肌病 PR间期 左室流出道压力阶差 

分 类 号：R542.2[医药卫生—心血管疾病] R540.41[医药卫生—内科学]