吡拉西坦片中有关物质测定方法的研究  

Determination the Related Substances of Piracetam Tablets by HPLC

作　　者：李明 王晓琦 王永新 

机构地区：[1]沧州市食品药品检验所,沧州061000

出　　处：《中国药品标准》2014年第1期45-46,共2页Drug Standards of China

摘　　要：目的:建立测定吡拉西坦片中有关物质的方法。方法:采用高效液相色谱法,色谱柱为Agilent C18(4.6 mm×250 mm,5μm),流动相为甲醇-水(10∶90),检测波长210 nm,流量1.0 mL·min-1。结果:吡拉西坦与其降解产物在该色谱条件下能够有效分离。结论:所建方法简便,专属性强,可用于测定吡拉西坦片中有关物质。To establish an HPLC method for determination the related substance of piracetam tablets. Method： The HPLC was carried out with C1s column, the mobile phase was a mixture of methanol and water（ 10： 90）, the wavelength was 210 nm and the flow rate was about 1.0 mL .min-l. Result： Piracetam and its related substances could be separated effectively by this method. Con clusion： The method is simple and reliable. It can be used to determine the related substance of piracetam tablets.

关 键 词：高效液相色谱法 吡拉西坦 有关物质 

分 类 号：R921.2[医药卫生—药学]