树舌多糖与抗肿瘤化疗药物联合应用的效果  

Effect on Combined Application of GAP and Anticancer Drugs

作　　者：胡静[1] 杜金[1] 杨扬[1] 邢亚丽[1] 刘秀明[2] 宋慧[1,3] 

机构地区：[1]吉林农业大学生命科学学院,长春130118 [2]吉林农业大学生物反应器与药物开发教育部工程研究中心,长春130118 [3]吉林农业大学食用菌教育部工程研究中心,长春130118

出　　处：《吉林农业大学学报》2014年第1期40-43,共4页Journal of Jilin Agricultural University

基　　金：吉林省世行贷款农产品质量安全项目(2011-Y18)

摘　　要：以S180肉瘤小鼠为模型,随机分为阴性对照组、树舌液体深层发酵浸膏多糖[Ganoderma applanatum(Pers.)Pat,GAP]组、环磷酰胺(Cyclophosphamide,CTX)组与联合用药组,连续灌胃8 d后,测定其抑瘤率、胸腺指数、脾指数,及对机体分泌肿瘤坏死因子(TNF-α)、白细胞介素2(IL-2)的影响,探讨GAP与CTX联合应用的抗肿瘤作用效果。结果表明:GAP与CTX合用抑瘤率比单用时明显升高,对免疫器官有显著影响(P<0.01),GAP与CTX联合应用组小鼠血清中IL-2、TNF-α的分泌量较CTX组有不同程度的增加。GAP能减轻CTX的毒副作用。说明树舌多糖GAP对抗肿瘤药物具有明显的增效减毒作用,是一种有效的抗肿瘤辅助药。In vivo,the mice of S1 80 sarcoma were randomly divided into negative control group,GAP group,CTX group and combination group,tumor-inhibiting rate and thymus index and spleen index were measured after eight days and tumor pathology was analyzed .Immune cells activities include NK cells and expression of necrosis factor （TNF-α）and interleukin 2 （IL-2）.The effects of Ganoderma applanatum （Pers .）Pat （GAP）combined with anticancer drugs were analyzed .Results：In vivo,tumor-inhibiting rate of GAP combined with CTX increased significantly compared with GAP or CTX alone （P＆lt;0.01 ）, the group of GAP combined with CTX had obvious effect on immune organs,GAP combined with CTX could reduce the by-effect of CTX and enhance body lymphatic cell′s activity and the activity of macrophages and the killing activity of NK cell,and it could also promote the secretion of TNF-αand IL-2 .Conclusion：GAP could markedly inhibit the growth of tumor cell,GAP combined with CTX could re-duce the by-effect of CTX,so the study on developing GAP into a chemotherapy drug substitutes or an adjuvant in treatment is of great practical significance .

关 键 词：树舌液体深层发酵浸膏多糖 环磷酰胺 联合用药 增效减毒 

分 类 号：R285.5[医药卫生—中药学]