临床骨髓间充质干细胞移植治疗不同时期心肌梗死的研究进展与展望  

Research progress of mesenchymal stem cells transplantation treating Myocardial infarction during different periods

作　　者：李彬(综述)[1] 汤素琼(综述)[1] 刘敬辉(综述) 李耀发(综述) 杨浩(综述) 刘家明(综述)[5] 王汉生(综述)[5] 周建国(综述)[5] 

机构地区：[1]湖北省孝感市中心医院CT室,432000 [2]孝感市中医院 [3]湖北省孝感市惠民医院 [4]孝感市卫生监督局 [5]清华大学医学部基础医学院

出　　处：《国际护理学杂志》2014年第2期257-260,共4页international journal of nursing

摘　　要：间充质干细胞（mesenchymal stem cell,MSCs）是中胚层来源的具有自我更新及多向分化能力的干细胞,主要存在于全身结缔组织和器官间质中,以骨髓组织中含量最为丰富.在一定的诱导条件下能分化为成骨细胞、成软骨细胞、肌腱细胞、脂肪细胞、成纤维细胞、内皮细胞、神经细胞、骨骼肌细胞及心肌细胞等.近年来其在心肌梗死修复中的作用已有多方面的研究,多种细胞因子、骨髓间充质干细胞的培养代数、心肌梗死后的炎症因子及不同时间点的组织内环境等均可影响移植MSCs的增值与分化.本文即从以上几方面探讨移植时机对不同时期梗死心肌修复的影响.成人体内的干细胞虽然数量稀少,但由于其可塑性强,取材容易,可实现自体化治疗,避免了ES细胞或异体细胞治疗的免疫排斥、伦理和未知病源感染等问题.干细胞的研究进展极大地促进了生命科学研究和生物技术产业的发展,同时也预示着一些目前难以治愈的疾病可能由于干细胞的研究与应用而得到有效治疗,最近几年受到相关研究者和社会各阶层的广泛重视,笔者就此方面的研究现状展开综述.Mesenchymal stem cell have the ability of self updates and multi-directional differentiation,mainly existed in the connective tissue and organ interstitial,especially in the bone marrow tissue.Under the condition of certain induction,it can differentiate into osteoblasts,chondroblast,tendon cells,adipose cell,fibroblast,endothelial cells,nerve cell,skeletal muscle cell and myocardial cell etc.In recent years,the role of it in the restoration of myocardial infarction had been studied.Many factors can influence the MSCs＇transplantation and differentiation including many kinds of cytokines,the number of generation of mesenchymal stem cells,inflammatory cytokines after myocardial infarction and the organization environment at different time points and so on.In this paper,the author studied the effect of transplantation opportunity on infarction myocardial repair during different periods.Although adult stem cells in the body were rare,but due to its high plasticity,materials easily,it can realize the self treatment,avoid the ES cells or with treatment of immune rejection,ethics and unknown pathogenic infection and other problems.The research progress of stem cell has greatly promoted the development of the biological technical estate and research of life science,At the same time it also indicates some difficult to cure disease can probably get well be treated because of application and the research of stem cell.It was been paid close attention to.

关 键 词：间充质干细胞 心肌梗死 研究进展 

分 类 号：R473.5[医药卫生—护理学]