基础窦卵泡数对IVF/ICSI-ET超排卵周期卵巢反应的预测价值  

Prediction Values of bAFC on the Response to Ovary in the IVF/ICSI-ET Super Ovulation Cycle

作　　者：张晓莉[1,2] 姚元庆[1] 彭红梅[1] 王黎娜[2] 郭晓东[3] 王辉[4] 

机构地区：[1]解放军总医院妇产科,北京100853 [2]武警总医院妇产科,北京100049 [3]解放军第302医院,北京100039 [4]北京石景山医院,北京100043

出　　处：《现代生物医学进展》2014年第6期1009-1011,1021,共4页Progress in Modern Biomedicine

基　　金：国家自然科学基金青年科学基金项目(30901795)

摘　　要：目的:窦卵是女性宫腔内的泡状细胞,与女性卵巢的发育及功能密切相关。本研究针对体外受精(IVF)周期中基础窦卵泡数(antral follicle count,AFC)的变化情况,探讨AFC对卵巢反应的预测价值,为临床研究提供理论基础。方法:回顾性分析2012年1月至2012年12月在我院生殖医学中心接受体外受精-胚胎移植的157例患者的临床资料,根据基础窦卵泡数将所选病例分为A组(bAFC≥10)和B组(bAFC<10)。对比并分析两组研究对象的促性腺激素(Gn)的用量及使用时间、获卵数、人绒毛膜促性腺激素(HCG)注射日的血清中雌激素(E2)水平、受精率、临床妊娠率等。结果:A组患者的Gn用量、HCG日E2值、获卵数及临床妊娠率均显著高于B组,差异具有统计学意义(P<0.05);两组患者的年龄和基础卵泡刺激素水平差异显著且具有统计学意义(P<0.05);两组患者的不孕原因、不孕年限及助孕方式无明显差异(P>0.05)。结论:基础窦卵泡对体外受精女性促排卵周期的卵巢反应及助孕结局具有一定的预测价值,其数量的多少可作为促排卵过程中评价卵巢反应性的参考指标,应在临床进一步推广。Objective： The antral follicles are the intrauterine alveolar cells which is closely relative to the ovary growth and function of females. This study aims to exploring the predictive value for ovarian response by means of observing the changes of AFC levels during the in vitro fertilization （IVF） cycle so as to provide a theoretical basis for clinical research. Methods： A retrospective analysis was performed on the clinical data of 157 patients who were accepted the IVF-ET at the center of reproductive medicine in our hospital from January 2012 to December 2012. According to the bAFC, the selected patients were divided into two groups, namely, the group A（bAFC_〉 10） and group B （bAFC〈10）. Then the time and dose of Gn, the numbers of ovum, the levels of E2 in serum on the date of HCG injection, the rate of fertilization and pregnancy in the two groups were compared and evaluated. Results： The dose of Gn, the numbers of ovum, the levels orE2 in serum on the date of HCG injection and the rate of pregnancy in group A were higher than those of the group B with statistically significant differences（P〈0.05）; there were statistically significant differences about the age and the quantity of bAFC in the two groups （P〈0.05）; but there was no significant difference about the reasons and time of infertility and the assistant methods for pregnancy in the two groups （P〉0.05）. Conclusions： It is suggested that the quantity ofbAFC could predict the functions of women＇s ovary for those who were taken the in vitro fertilization and it might become an essential indicator in the future for the clinical to detect the ovarian reactions of the infertile females during the super ovulation cycles.

关 键 词：窦卵泡 体外受精 卵巢反应 促排卵 

分 类 号：R711.6[医药卫生—妇产科学]