儿童过敏性紫癜早期肾损伤中VCAM-1的临床意义  

Clinical Value of VCAM-1 in Early Renal Damage in Children Anaphylactoid Purpura

作　　者：傅卓[1] 任少敏[1] 高晓峰[1] 杨光路[1] 李筱贺[2] 

机构地区：[1]内蒙古医科大学附属医院儿科,内蒙古呼和浩特010050 [2]内蒙古医科大学基础医学院人体解剖教研室,内蒙古呼和浩特010110

出　　处：《现代生物医学进展》2014年第6期1095-1096,1100,共3页Progress in Modern Biomedicine

基　　金：内蒙古自治区卫生厅资助项目(2006022);内蒙古自然科学基金项目(2012MS1117);内蒙古医学院博士科研启动基金(BSJJ2011007)

摘　　要：目的:探讨血管细胞粘附分子-1(VCAM-1)的检测在儿童过敏性紫癜(AP)早期肾损伤中的临床意义。方法:选择明确诊断为AP患儿85例,均为早期无肾损害的AP病儿。根据第七版诸福棠实用儿科学有关章节的诊断标准和随访结果,进一步将研究对象分为有肾损害AP为APN组,无肾损害AP为AP组,于同时间、同群体中选择健康儿童35名为对照组。应用ELISA法分别检测三组患儿早期无肾损害时血VCAM-1的含量,分析血VCAM-1在儿童过敏性紫癜早期肾损伤中的临床意义。结果:APN组血VCAM-1水平均高于AP组和正常对照组;AP组亦高于正常对照组,差异均有统计学意义(P<0.01)。结论:对早期无肾损害的AP病儿,检测血浆VCAM-1对AP发生APN的预后诊断有重要的临床意义。Objective： To explore the clinical value of VCAM-1 in early renal damage in children anaphylactoid purpura. Methods： Eighty five children with non-renal involvement AP were enrolled in the study. The patients were divided into two groups, APN group and non-renal involvement AP group （the negative control group）, based on the diagnostic criteria in related part of seventh edition of Practical Pediatrics and the results of follow up. The plasm level of VCAM-1 was detected with ELISA to analyze the prognostic value of VCAM-1 in APN children and non-renal involvement A P children. Results： The level of VCAM-1 in A PN group was higher than that in AP group and normal control group. The level of VCAM-1 in AP group was higher than that in normal control group, and the difference was statistically significant（ P〈0.01 ）. Conclusion： The plasm level of VCAM-1 in children with non-renal involvement AP has important clinical significance in prognostic diagnose of AFN.

关 键 词：血管细胞粘附分子-1 过敏性紫癜 儿童 紫癜性肾炎 

分 类 号：R725[医药卫生—儿科]