低氧对MSCs增殖和分化的影响  

The Impact of Hypoxia on the Proliferation and Differentiation of MSCs

作　　者：王宇翔[1] 陶树清[1] 卜建龙[1] 

机构地区：[1]哈尔滨医科大学附属第二临床医学院骨二科,黑龙江哈尔滨150086

出　　处：《现代生物医学进展》2014年第6期1177-1179,1190,共4页Progress in Modern Biomedicine

摘　　要：间充质干细胞(mesenchymal stem cells,MSCs)是具有自我更新、多向分化和强可塑性的细胞,具有分化为血液、骨、软骨、脂肪、肌肉、表皮、上皮、神经等组织的潜能,受到再生医学研究的关注。目前已有研究表明将MSCs移植到多种损伤组织中都能改善损伤组织的功能。文章在简要回顾了低氧环境对MSCs增殖和分化的研究内容和有关理论争论基础上重点介绍了缺氧诱导因子(HIF)通路对MSCs增殖和分化的影响。文章阐述了低氧环境对MSCs向成骨,成软骨,成脂及成神经元方向分化的影响。由于人体组织内生理条件下的氧张力远远小于大气中的氧张力(21%),采用低氧培养MSCs的研究方法得出的结论将更加贴近实际MSCs在人体内的增殖、分化情况。因此研究MSCs在低氧张力环境中增殖、分化的能力将为MSCs能成功移植到体内并发挥作用提供保障。Mesenchymal stem cells （mesenchymal stem cells, MSCs） have the function of self-renewal, multi-differentiation and strong plasticity, which have the potential to differentiation as blood, bone, cartilage, fat, muscle, epidermis, epithelial, nerve tissue, and have been concerned of regenerationthe medical research. Studies have shown that MSCs transplantation can improve the function of the damaged tissue to a variety of injured tissues. The article briefly reviews the hypoxic environment on the proliferation and differentiation of MSCs content and related theory highlights the controversy on the basis of the hypoxia-inducible factor （HIF） pathway on the proliferation and differentiation of MSCs. The article explains the hypoxic environment of MSCs to differentiate into bone, cartilage, adipogenic differentiation into neurons affect. Under physiological conditions in human tissue oxygen tension is much less than atmospheric oxygen tension （21%）, hypoxic of MSCs concluded will be closer to the actual MSCs proliferation and differentiation in the human body. Therefore, study MSCs proliferation, differentiation capacity for MSCs can be successfully transplanted into the body and play a role in providing protection in a low oxygen tension environment.

关 键 词：间充质干细胞 低氧 细胞增殖 细胞分化 再生医学 

分 类 号：R329.2[医药卫生—人体解剖和组织胚胎学] R68[医药卫生—基础医学]