铜绿假单胞菌的临床分布及耐药性分析  

作　　者：左江华[1] 宋红芳[2] 杨雪晶[3] 任宏涛[1] 田连芳[1] 李书君[1] 

机构地区：[1] 邢台市人民医院检验科, 河北 邢台 054000 [2] 邢台市疾病预防控制中心, 河北 邢台 054000 [3] 邢台市人民医院麻醉科, 河北 邢台 054000

出　　处：《医学美学美容（中旬刊）》2014年第3期1-2,共2页

摘　　要：目的：了解医院铜绿假单胞菌的临床分布及耐药性，对临床合理用药进行指导，及时切断多重耐药菌株的传播。方法：分析本市人民医院2012年8月-2013年7月住院患者送检的各类标本进行病原菌培养与鉴定，药敏试验采用纸片扩散法，使用WHONET 5.4软件进行耐药性分析。结果：共分离450株铜绿假单胞菌，其中来自呼吸道的标本348株；450株铜绿假单胞菌中集中分布在ICU、、神经外科、儿科、烧伤科和神经内科，共266株，占总数的59.1%；耐药率最高的是头孢唑林，为99.6%，最低的是阿米卡星，为11.6%，对亚胺培南和美罗培南的耐药率为42.9%和39.3%。结论通过分析铜绿假单胞菌临床分布并监测其耐药性，可指导临床合理使用抗菌药物，并有效控制和延缓细菌耐药的发生。Objective：To investigate the clinical distribution and drug resistance of Pseudomonas aeruginosa, to guide clinical rational drug use, cut off the transmission of multi drug resistant strains in time. Methods：analysis of the city people＆#39;s Hospital in 2012 August -2013 year in July in various specimens were col-lected for culture and identification of pathogenic bacteria, drug sensitivity test was performed by disk diffusion method, WHONET 5. 4 software was used foy analy-sing the drug resistance. Results：there were 450 strains of Pseudomonas aeruginosa, including 348 strains from the respiratory tract specimens;450 strains of Pseud-omonas aeruginosa were concentrated in ICU, Department of Neurosurgery, pediatrics, Department of burn, Department of neurology and Department of thoracic sur-gery , there were 266 strains, accounting for 59. 1% of the total;drug resistance rate is the highest for cefazolin, 99. 6%, the lowest is Amikacin,11. 6%, resistant to imipenem and meropenem were 42. 9% and 39. 3%. Conclusions：Through analysing Pseudomonas aeruginosa’s clinical distribution and monitor the resistance, it can be used to guide the clinical rational use of antimicrobial agents, and effectively control and delay the occurrence of bacterial drug resistance.

关 键 词：铜绿假单胞菌 临床分布 耐药性 

分 类 号：R446.5[医药卫生—诊断学]