携带HBsAg孕妇产前注射HBIG阻断宫内传播的Meta分析  

Meta-analysis on the effect of hepatitis B immunoglobulin intrauterine injection on interrupting hepatitis B virus mother-to-child transmission

作　　者：安淑一[1,2] 赵卓[2] 郭军巧[2] 韩悦[2] 王作虪[2] 吴伟[1] 周宝森[1] 

机构地区：[1]中国医科大学公共卫生学院流行病与卫生统计系,辽宁沈阳110001 [2]辽宁省疾病预防控制中心,辽宁沈阳110005

出　　处：《中华疾病控制杂志》2014年第3期231-235,共5页Chinese Journal of Disease Control & Prevention

基　　金：国家自然科学基金(30771860);青年科学基金(81202254)

摘　　要：目的评价孕妇产前应用乙型肝炎免疫球蛋白（hepatitis Bimmune globulin，HBIG）阻断乙型肝炎病毒（hepatitis B virus，HBV）宫内传播的效果。方法查阅国内外有关孕妇产前使用HBIG阻断宫内传播的研究，收集出生及1岁婴儿乙肝表面抗原（hepatitis B surface antigen，HBsAg）检测情况，通过Stata12．0软件进行Meta分析，获得合并RR值。结果新生儿随机效应模型干预组与对照组合并RR值为0．37，95％CI：0．23—0．61；1岁婴儿随机效应模型干预组与对照组合并RR值为0．48，95％CI：0．27～0．84。结论应用HBIG200IU可以有效阻断乙肝病毒的官内传播。Objective To evaluate the effects of hepatitis B immunoglobulin （HBIG） intrauterine-injection before delivery on interrupting mother-to-child transmission of hepatitis B virus （HBV）. Methods The randomized controlled tri- Ms on HBIG intrauterine injection on interrupting mother-to-child transmission of HBV published from January 1995 to May 2013 were searched. The data were extracted and analyzed by STATA software. Results Results of the meta-analysis indi- cated that the infant HBV infection relative risks with random effects models in the HBIG group and the control group were 0.37（95% Cl：0. 23-0. 61） at birth ,O. 48（95% CI：0.27-0.84）on 1 year. Conclusions Injection of HBIG during pregnancy with possitive HBV can effectively reduce the vertical transmission of HBV.

关 键 词：肝炎 乙型 慢性 肝炎表面抗原 乙型 META分析 

分 类 号：R181.2[医药卫生—流行病学] R512.62[医药卫生—公共卫生与预防医学]