In Vivo Magnetic Particle Targeting by Local Gradient Field of Interstitial Seeds Magnetized in an Ex Vivo Uniform Field  

作　　者：李晓强 郑路 王旭飞 

机构地区：[1]Institute of Modern Physics, Pudan University, Shanghai 200433 [2]Department of Physics, Fudan University, Shanghai 200433 [3]Applied Ion Beam Physics Laboratory, Fhdan University, Shanghai 200433

出　　处：《Chinese Physics Letters》2014年第2期78-82,共5页中国物理快报（英文版）

基　　金：Supported by the National Basic Research Program of China under Grant No 2013AA032202, and the National Natural Science Foundation of China under Grant Nos 11005019 and 11375047.

摘　　要：The possibility of in vivo magnetic particle targeting by the locally induced gradient field of interstitial ferro- magnetic implants, magnetized in an ex vivo uniform field, is evaluated by a modelling analysis. A simplified 3D model analogous to a torso size, with a continuous laminar flow through the volume with the typical velocity and viscosity values of in vivo blood flow and a ferromagnetic seed inserted in the volume center vertical to the flow, is used to evaluate the magnetic particle capturing efficiency by the seed, which is magnetized in a uniform field. The initial modelling results indicate that for 1-10μm iron oxide particles transporting with a blood flow of 0.5-5 mm/s, the seeds of tungsten steel, magnet steel and cast cobalt all present an effective particle capturing efficiency, which shows a fast initial increase and a slow saturation with the increasing magnetic field, a quasilinear increase with the increasing particle size, and a nonlinear decrease with the increasing blood velocity.The possibility of in vivo magnetic particle targeting by the locally induced gradient field of interstitial ferro- magnetic implants, magnetized in an ex vivo uniform field, is evaluated by a modelling analysis. A simplified 3D model analogous to a torso size, with a continuous laminar flow through the volume with the typical velocity and viscosity values of in vivo blood flow and a ferromagnetic seed inserted in the volume center vertical to the flow, is used to evaluate the magnetic particle capturing efficiency by the seed, which is magnetized in a uniform field. The initial modelling results indicate that for 1-10μm iron oxide particles transporting with a blood flow of 0.5-5 mm/s, the seeds of tungsten steel, magnet steel and cast cobalt all present an effective particle capturing efficiency, which shows a fast initial increase and a slow saturation with the increasing magnetic field, a quasilinear increase with the increasing particle size, and a nonlinear decrease with the increasing blood velocity.

分 类 号：TQ455.021[化学工程—农药化工] O413.1[理学—理论物理]