颈动脉内中膜厚度与H型高血压及相关因素的分析  

Analysis on carotid intima-media thickness, H type of hypertension and related factors

作　　者：杨虹[1,2] 田凤石[3] 

机构地区：[1]天津医科大学研究生院,天津300070 [2]天津市公安医院物检科,天津300042 [3]天津市第四中心医院心内科,天津300140

出　　处：《天津医科大学学报》2014年第2期137-139,共3页Journal of Tianjin Medical University

摘　　要：目的:探讨颈动脉内中膜厚度与H型高血压及相关因素的关系。方法:选取244例高血压患者,根据同型半胱氨酸(Hcy)水平分为H型高血压组(Hcy≥10μmol/L)、非H型高血压组(Hcy<10μmol/L),测量颈动脉内中膜厚度(IMT),观察有无斑块、斑块位置及类型,计算斑块积分并测量血甘油三酯(TG)、胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)等指标;同时收集年龄、性别、病程等流行病学资料。结果:H型高血压组颈动脉IMT、斑块积分、斑块检出率、合并脑梗死及冠心病构成比均高于非H型高血压组,两组间差异有统计学意义(P<0.05)。相关分析显示:颈动脉IMT与Hcy、空腹血糖(FBG)、HDL-C、年龄及高血压病程有相关性。结论:H型高血压与颈动脉内中膜厚度密切相关,高同型半胱氨酸可在高血压的基础上加速动脉硬化的进程。Objective： To investigate the relationship of carotid intima-media thickness （IMT） and H-type hypertension as well as its relevant factors. Methods： According to their levels of Hcy, 244 patients were divided into two groups： the H-type hypertension group （Hcy ≥ 10 μmo/L） and non-H-type hypertension group （Hcy〈 10 p^mol/L）. Carotid intima-media thickness was measured and the location and type of plaque were observed. Meanwhile, the plaque integral was calculated and the blood triglycerides, cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol and other indicators were all measured epidemiological data such as age, gender, duration were collected. Results： In the H-type hypertension group, the factor values of IMT, plaque score, plaque detection rate, merging, cerebral infarction and coronary heart disease were higher than those in non-H-tyne hypertension group （P〈0.05）. Analysis showed that IMT was correlated with Hcy and FBG, HDL-C, age as well as hypertension duration. Conclusion： The high incidence of H- type hypertension is related to IMT. High homocysteine can accelerate the process of arteriosclerosis in the condition of hypertension.

关 键 词：“H型”高血压 超声 颈动脉内中膜厚度 颈动脉斑块 

分 类 号：R544.1[医药卫生—心血管疾病]