脑梗死恢复早期实证患者的二级预防模式研究  

Research on the secondary prevention schemes in treating excess-syndrome cerebral infarction patients at early recovery stage

作　　者：王嘉麟[1] 邢佳[1] 朱晓晨[1] 郭蓉娟[1] 张允岭[1] 李麒豫[1] 王椿野[1] 贺立娟[1] 耿东[1] 史华伟[2] 刘旭[1] 杜雅薇[3] 齐锡友 董致郅[4] 王玲玲 孟宪慧 

机构地区：[1]北京中医药大学东方医院脑病二科,100078 [2]中医药大学东方医院脑病二科,博士研究生100078 [3]北京中医药大学东直门医院药理基地 [4]北京市怀柔区中医医院神经内科 [5]右安门社区卫生服务中心内科

出　　处：《环球中医药》2014年第3期172-176,共5页Global Traditional Chinese Medicine

基　　金：首都医学科研发展基金(SF-2009-Ⅱ-07);2011年北京市科技计划(Z111100056811040);北京中医药大学创新团队项目(2011-CXTD-23)

摘　　要：目的比较三种脑梗死恢复早期实证患者二级预防模式的疗效,以求最佳治疗方法。方法随机纳入脑梗死恢复早期实证患者150例,其中解毒通络+调摄情志+基础治疗组50例,解毒通络+基础治疗组50例与单纯基础治疗组50例,治疗3个月,随访6个月,比较3种干预模式对脑梗死恢复早期实证患者的病残恢复程度、生活质量的影响。结果经秩和检验,无论是治疗期还是随访期,三组在CSS与ADL评分方面差异有统计学意义(P<0.01)。经两两比较,解毒通络+基础治疗组与解毒通络+调摄情志+基础治疗组的疗效均明显高于基础治疗组,但解毒通络+基础治疗组与解毒通络+调摄情志+基础治疗组两组之间无显著统计学差异(P>0.05)。结论在西医治疗的基础上,联合中医解毒通络药物,能明显提高脑梗死恢复早期实证患者的临床疗效,减轻病残程度,改善生活质量,但加用中医调摄情志法后尚未提高疗效,有待探索。Objective To compare the efficacy of three secondary prevention schemes in treating cerebral infarction patients （early recovery stage） with excess syndrome, in order to achieve the best treat- ment efficacy. Methods We enrolled 150 patients of excess syndrome with cerebral infarction during early recovery randomly,including 50 cases of Jiedu Tongluo ＋ adjust emotion ＋ foundation treatment group, 50 cases of Jiedu Tongluo ＋ adjust emotion group, and 50 cases of foundation treatment group, who were trea- ted for three months and followed up for six months, to compare the effect on disability degree of recovery and quality of life among the prevention modes of the patients of sthenia syndrome with cerebral infarction during early recovery. Results Regardless of treatment or follow-up period, according to rank sum test, there was a statistically significant difference among the three groups score in CSS and ADL （ P 〈 0. 01 ）. After the pairwise comparison,curative effect of ＇ Jiedu Tongluo ＋ foundation treatment group＇ and ＇ Jiedu Tongluo ＋ adjust emotion ＋ foundation treatment group＇ was significantly higher than foundation treat- ment group, but ＇ Jiedu Tongluo ＋ foundation treatment group＇ and ＇ Jiedu Tongluo ＋ adjust emotion ＋ foundation treatment group＇ had no significant between the two groups （ P 〉 0. 05 ） . Conclusion Based on Western Medicine, combined with Jiedu Tongluo formula of traditional Chinese medicine, the clinical efficacy in treating excess-syndrome cerebral infarction patients at early recovery stage can be significantly enhanced with disability level lowered, the quality of life improved, but when emotion regulation method was brought in, no better therapeutic effects were achieved.

关 键 词：脑梗死恢复期 二级预防 毒邪 

分 类 号：R277.7[医药卫生—中医学]