受体肝纤维化大鼠小体积肝移植模型的建立  

Establishment of small-size liver transplantation model for cirrhotic rats

作　　者：苏明[1] 陈永亮[1] 万钧[2] 

机构地区：[1]解放军总医院肝胆外科,北京100853 [2]香港大学肝病研究中心外科系

出　　处：《解放军医学院学报》2014年第3期270-272,共3页Academic Journal of Chinese PLA Medical School

摘　　要：目的建立稳定的受体肝纤维化大鼠小体积肝移植模型。方法采用肝纤维化的SD大鼠,行56.3%比例的小体积肝移植12例,95.8%比例的全肝移植12例。结果成功构建了受体肝纤维化大鼠小体积肝移植模型;受体肝纤维化大鼠的全肝移植组术后24 h肝功能、7 d生存率明显优于小体积肝移植组(P<0.05)。结论成功建立了受体肝纤维化大鼠小体积肝移植模型,可作为相关研究的有效动物实验平台。Objective To establish the small-size liver transplantation model for cirrhotic rats. Methods Of the 24 SD cirrhotic rats,12 underwent small-size liver transplantation （56.3%） and 12 underwent whole liver transplantation （95.8%）. Results The small-size liver transplantation model was successfully established for cirrhotic rats. The liver function 24 h after operation and the 7-day survival rate were significantly higher in whole liver transplantation group than in small-size liver transplantation group （P＆lt;0.05）. Conclusion The small-size liver transplantation model for cirrhotic rats can be used as an animal experiment platform for liver transplantation-related research.

关 键 词：肝移植 肝纤维化 小体积供肝 动物模型 

分 类 号：R657.3[医药卫生—外科学]